Acute Suppurative Osteomyelitis
Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for acute suppurative osteomyelitis. Inflammation of the bone marrow caused by bloodstream infection with purulent bacteria is called acute osteomyelitis. The pathogenic bacteria are often Staphylococcus aureus, and the primary lesions are mostly abscesses. Various inflammations cause sepsis and invade the bone marrow. At Alta Stomatology, we're dedicated to offering one-stop services for acute suppurative osteomyelitis research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Subacute suppurative mandibular osteomyelitis after dental extraction (Koorbusch GF, et al., 2011)
Research on Acute Suppurative Osteomyelitis
Osteomyelitis of the jaw is a relatively rare infectious disease caused by systemic diseases such as hematogenous, bone disease or vascular disease, and odontogenic or non-odontogenic local infection in the oral and maxillofacial region. Osteomyelitis can be classified into two types: acute suppurative osteomyelitis and chronic suppurative osteomyelitis. Acute suppurative osteomyelitis develops shortly after the predisposition occurs and is accompanied by systemic symptoms such as severe pain, tenderness, swelling, fever, and malaise. This osteomyelitis is not completely cured even with appropriate treatment and lasts for 1 to 4 months or longer.
Acute osteomyelitis of the jaws is caused mostly by a bacterial focus (odontogenic disease, pulpal and periodontal infection, extraction wounds, foreign bodies, and infected fractures). Mercuri (1991) and Marx (1991) arbitrarily defined the time element as being 1 month after onset of symptoms. Endurance past this arbitrary set time limit is then considered as chronic osteomyelitis reflecting the inability of host defense mechanisms to eradicate the responsible pathogen.
Our Products
IHC Automatized Platform
DAB Chromogen
Antihuman Monoclonal Dako
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on acute suppurative osteomyelitis and and its prevention and treatment. Histopathology is crucial for understanding pathological processes accompanying diseases. To better understand acute suppurative osteomyelitis, it is important to carry out careful histopathological examinations. Accurate microbiological diagnosis is a cornerstone in management of osteomyelitis.
| Histological and Immunohistological Analysis |
Microbiological Diagnosis |
- Hematoxylin and eosin (H&E) staining
- Immunohistochemistry (IHC) staining
- Masson's trichrome (MT) staining
|
- Blood testing
- PCR
- Bacterial pathogen detection
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For acute suppurative osteomyelitis diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of acute suppurative osteomyelitis. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of jaw disease.
| Diagnosis Methods |
Description |
| Micro Computed Tomography |
Micro-CT analysis tools provide a highly reproducible methodology with qualitative and quantitative assessment of bone microstructure. Micro-CT is considered to be a gold standard method for assessing mineral density, bone morphology, and bone micro-architecture under various pathological conditions. |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the jaw, enabling our experts to accurately identify lesions occurring in the jaw. |
| Cone Beam Computed Tomography (CBCT) |
Cone beam computed tomography (CBCT) is a CT technique that uses far less radiation than conventional CT and captures multiple views of the patient in a single 360° rotation. The information thus obtained is then processed and reconstructed in different planes (multiplanar reconstruction) and, if necessary, three-dimensionally as well. |
References
- Baltensperger M, et al. Osteomyelitis of the Jaws: Definition and Classification. Osteomyelitis of the Jaws. 2009; 5-56.
- Koorbusch GF, et al. How can we diagnose and treat osteomyelitis of the jaws as early as possible? Oral Maxillofac Surg Clin North Am. 2011; 23(4):557-67.
For research use only. Not
intended for any clinical use.
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