Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for adenomatoid odontogenic tumor. Adenomatoid odontogenic tumor is composed by solid nodules of epithelial, fusiform or cuboidal cells which form a cluster, as well as characteristics of duct-like spaces and epithelial bands with cancellous or cribiform configuration. At Alta Stomatology, we're dedicated to offering one-stop services for adenomatoid odontogenic tumor research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Tubular-like structures with calcified areas (Risk DC, et al., 2015)

Research on Adenomatoid Odontogenic Tumor

Adenomatoid odontogenic tumor (AOT) is a rare tumor of epithelial origin comprising 3% of all the odontogenic tumors. It is a benign, painless, noninvasive, and slow-growing lesion, with a relative frequency of 2.2-13% and often misdiagnosed as an odontogenic cyst on clinical examination. AOT affects young individuals with a female predominance, occurs mainly in the second decade, and usually surrounds the crown of unerupted teeth. This lesion is most commonly located in the anterior maxilla and rarely in the mandible.

Generally, AOT occurs intraosseously, but can also occur rarely in peripheral locations. There are three variants of AOT: follicular, extrafollicular, and peripheral. The follicular type (pericoronal) is a central intrabony lesion associated with an unerupted tooth, which accounts for about 70% of all cases. The extrafollicular type (extracoronal) is also an intraosseous lesion, but unrelated to an unerupted tooth, and represents 25% of all AOTs. The peripheral type (extra osseous) is a rare form that arises in the gingival tissue, and accounts for 5% of all AOTs. All the variants of AOT show identical histological features.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on adenomatoid odontogenic tumor and and its prevention and treatment. Understanding the molecular signatures can aid in the diagnosis of adenomatoid odontogenic tumor disease and help identify potential molecular targets for future treatments.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For adenomatoid odontogenic tumor disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of adenomatoid odontogenic tumor. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease. 

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service