Alta Stomatology is a company specializing in the research and development of oral disease drugs. We offer a range of high-throughput ADME screening as well as drug metabolism and pharmacokinetics (DMPK) services to support the development of oral disease drugs. Our scientists possess extensive expertise in drug development, bioanalysis, chemical analysis, and other relevant fields, enabling us to cover all aspects of ADME and DMPK testing to facilitate the development of oral disease drugs. If you have any needs, please feel free to contact us.
Our Services
At Alta Stomatology, we provide a range of ADME/DMPK services tailored to meet the diverse needs of our clients. Whether conducting in vitro assays to assess drug metabolism or performing pharmacokinetic studies in animal models, our team delivers accurate, timely, and actionable data to drive informed decision-making throughout the drug development process.
In Vitro ADME Services
Our in vitro ADME services encompass a wide array of assays designed to evaluate the absorption, distribution, metabolism, and excretion properties of drug candidates. Leveraging advanced techniques and cutting-edge technologies, our scientists can assess factors such as permeability, solubility, protein binding, and pharmacokinetic.
| Solubility assessments |
Lipophilicity (LogP, LogD and pKa) |
| Stability (buffer, pH, plasma etc.) |
Blood cell partitioning |
| CYP450 inhibition |
CYP450 reaction phenotyping |
| CYP450 induction |
Non-CYP metabolism |
| Metabolic stability - microsomes, S9 |
Metabolic stability - hepatocytes |
| Permeability and efflux |
ABC/SLC transporters |
| Matrix protein binding |
Melanin binding |
| Plasma protein binding across species, rapid equilibrium dialysis (RED), high-throughput dialysis, etc. |
In Vivo PK/ADME Services
Alta Stomatology offers comprehensive in vivo PK/ADME services conducted in relevant animal models. Our experienced team designs and executes studies to investigate the pharmacokinetic behavior of compounds following oral, intravenous, or other routes of administration. By quantifying key parameters such as bioavailability, clearance, and tissue distribution, we generate critical data to support dose selection, formulation optimization, and regulatory submissions.
| Screening PK |
In vivo PK models |
PK/PD analysis |
| Tissue distribution studies |
Excretion studies |
Biliary and urine excretion studies |
| Mass balance studies |
Blood/plasma pharmacokinetic studies |
Drug concentration in tissues |
| Unbound level in tissue |
Metabolite analysis |
Metabolite quantification |
| Drug-drug interaction studies |
Bioavailability and bioequivalence studies |
Evaluate elimination and absorption rates |
Why Choose Alta Stomatology?
With decades of experience in ADME/DMPK research, our team comprises seasoned scientists and industry veterans who possess a deep understanding of oral disease pharmacology.
- State-of-the-Art Infrastructure
Our platforms are equipped with state-of-the-art instrumentation and technology, enabling us to conduct a wide range of ADME/DMPK studies with precision and efficiency. From high-performance liquid chromatography (HPLC) systems to mass spectrometers and cell culture facilities, we advanced facilities enable us to deliver reliable and reproducible data.
- Commitment to Quality and Compliance
At Alta Stomatology, quality and compliance are paramount in everything we do. We adhere to rigorous quality control measures and regulatory guidelines to ensure the integrity, reliability, and confidentiality of our services.
- Customized Solutions for Oral Disease Drug Development
Unlike generic ADME/DMPK service providers, Alta Stomatology specializes in the unique challenges of oral disease drug development. We tailor services to address the specific requirements and complexities of oral drug delivery, formulation optimization, and target tissue distribution, ensuring that your drug candidates achieve their full therapeutic potential.
For research use only. Not
intended for any clinical use.
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