Ameloblastic Fibrodentinoma And Ameloblastic Fibro-Odontoma
Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for ameloblastic fibrodentinoma and ameloblastic fibro-odontoma. Ameloblastic fibrodentinoma is a rare benign odontogenic tumor with histopathological features of ameloblastic fibroma and the formation of dysplastic dentin. Ameloblastic fibro-odontoma is a slow-growing, expansive, benign mixed odontogenic tumor that is histologically similar to ameloblastic fibrodentinoma but also contains enameloid material in variable amounts. At Alta Stomatology, we're dedicated to offering one-stop services for ameloblastic fibrodentinoma and ameloblastic fibro-odontoma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Histological section. Ameloblastic fibro-odontoma (Marie C, et al., 2020)
Research on Ameloblastic Fibrodentinoma And Ameloblastic Fibro-Odontoma
Ameloblastic fibroma (AF) consists of odontogenic ectomesenchyme resembling the dental papilla and epithelial strands and nests resembling dental lamina and enamel organ. No dental hard tissues are present. Rarely, tumors with the histomorphology of AF may form dysplastic dentin, and are called ameloblastic fibrodentinomas (AFD), or dentin plus enamel, and be classified as ameloblastic fibro-odontoma (AFO). The true AFD and AFO, not the developmental odontoma, are considered to be rare lesions.
AFD is a slow-growing lesion. It is usually an asymptomatic lesion and more frequently involves the posterior part of mandible. It occurs in younger age group. Common signs and symptoms of AFO are asymptomatic swelling, delayed tooth eruption in the affected region and a well-defined mixed radiological appearance that is similar to other odontogenic neoplastic formations, such as immature complex odontoma, calcifying epithelial odontogenic tumor and adenomatoid odontogenic tumor.
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on ameloblastic fibrodentinoma and ameloblastic fibro-odontoma, and and its prevention and treatment. The advances in molecular technologies have allowed a better understanding of the molecular basis of odontogenic cysts and tumors. Histopathology helps determine the final diagnosis of the disease and differentiate the lesions.
| Molecular Characterization Investigation |
Histopathological Analysis |
- Direct sequencing
- Next-generation sequencing
- PCR
|
- Tissue embedding and sectioning
- Hematoxylin and eosin staining
- Protein expression study
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For ameloblastic fibrodentinoma and ameloblastic fibro-odontoma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of ameloblastic fibrodentinoma and ameloblastic fibro-odontoma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. |
| Optical Microscope |
The optical microscope, also referred to as a light microscope, is a type of microscope that commonly uses visible light and a system of lenses to generate magnified images of small objects. The stained tissue sections can be observed through an optical microscope to determine the tumor status. |
References
- Chrcanovic BR, Gomez RS. Ameloblastic Fibrodentinoma and Ameloblastic Fibro-Odontoma: An Updated Systematic Review of Cases Reported in the Literature. J Oral Maxillofac Surg. 2017;75(7):1425-1437.
- Marie C, David DP. A rare case of maxillary ameloblastic fibro-odontoma and a review of the literature. Journal of Oral Medicine and Oral Surgery. 2020; 26(2): 17.
For research use only. Not
intended for any clinical use.
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