Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for ameloblastic fibroma. The ameloblastic fibroma is a tumor composed of odontogenic ectomesenchyme resembling the dental papilla with epithelial strands and nests similar to the dental lamina and enamel organ, but with no dental hard tissues. At Alta Stomatology, we're dedicated to offering one-stop services for ameloblastic fibroma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Microphotograph of ameloblastic fibroma with odontogenic epithelium embedded in cellular mesodermal tissue (Mullapudi S.V., et al., 2011)
Research on Ameloblastic Fibroma
Ameloblastic fibroma (AF) is considered as an uncommon, slowly-growing benign odontogenic neoplasm in the posterior area of the mandible. AF occurring at any age, but has a predilection to present in age group of 7-61 years with 80% in patients younger than 22 years. AF clinically exists as a well circumscribed swelling with slight cortical bone expansion and may cause displacement of the adjacent teeth. Simple surgical excision is the best treatment in the majority of AF cases.
Ameloblastic fibromas are rare and comprise approximately 2% of odontogenic tumors. Radiographically, ameloblastic fibromas are unilocular lesions, occasionally multilocular when larger, with smooth well-demarcated borders. Cortical expansion may or may not be discernable on plane film. Histologically, it usually composed of islands and cords of odontogenic epithelial tumor cells immersed in ectomesenchyme (resemble the dental papilla) but without any actual hard dental tissue formation. Grossly, ameloblastic fibroma appears as firm, lobular soft tissue mass with a smooth surface.
Our Products
QIAamp DNA Mini Kit
Vimentin Antibody
Pancytokeratin Antibody
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on ameloblastic fibroma and and its prevention and treatment. The understanding of the core genetic changes in odontogenic tumors could refine their classification, aid in the diagnoses of challenging lesions, and help in the design of new targeted therapies for aggressive and/or malignant cases.
| Molecular Pathology Analysis |
Histopathological Analysis |
- Direct sequencing
- Next-generation sequencing
- qPCR
- Sanger sequencing
|
- Tissue embedding and sectioning
- Staining: silver staining, hematoxylin and eosin staining
- Protein expression study
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For ameloblastic fibroma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of ameloblastic fibroma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Immunohistochemistry Assessment |
Immunohistochemistry is one of the most widely used protein detection techniques. The principle of this technique is based on the binding of a specific antibody to a matching specific antigen in tissue. The findings of immunohistochemistry can evaluate the growth potential in ameloblastic fibroma, which could be of help in understanding tumor aggressiveness. |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. |
References
- Nelson B.L., Folk G.S. Ameloblastic Fibroma. Head and Neck Pathol. 2009; 3: 51-53.
- Mullapudi S.V., et al. Odontogenic tumors and giant cell lesions of jaws - a nine year study. World J Surg Onc 9. 2011; 68.
For research use only. Not
intended for any clinical use.
