Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for ameloblastoma. Ameloblastoma is a benign tumor originating in the odontogenic epithelium without ectomesenchyme, affecting the maxillo-mandibular complex. It is an asymptomatic lesion, and it presents locally invasive behavior, and higher recurrence rates. At Alta Stomatology, we're dedicated to offering one-stop services for ameloblastoma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Follicular ameloblastoma showing peripheral palisading and central reticulum stellate pattern (Hertog D, et al., 2012)

Research on Ameloblastoma

Ameloblastoma is the most common benign tumor of the jaws, comprising 1% of all cysts and tumors of the jaws and approximately 10%-18% of odontogenic tumors, with 80% occurring in the mandible and 20% in the maxilla. The most common presenting symptom is a painless swelling. Other symptoms include loosening of teeth, malocclusion and altered sensation in the teeth and occasionally pain. It is usually present within the bone, however, it can also be found in the soft tissues (peripheral ameloblastoma). It is classified into solid and cystic or multicystic variants. In the solid variant, a variety of histopathologic patterns can be seen, such as follicular, plexiform, desmoplastic, basal cell, acanthomatous, and granular cell.

Current treatment of ameloblastoma involves extensive surgical excision because the tumor has a high recurrence rate. For large lesions that destroy crucial anatomic structures in the jaw, the surgical procedures often lead to high morbidity and difficult rehabilitation. Numerous studies can explain the molecular pathogenesis of ameloblastoma. Every cellular change, including proliferation, differentiation and tumorigenesis occurs through the activation or inactivation of the related molecular signaling pathways. The important signaling molecules are either overexpressed or underexpressed during tumorigenesis of ameloblastomas.

Our Products 

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on ameloblastoma and and its prevention and treatment. Ameloblastoma demonstrates various histological forms, such as the follicular and the plexiform types, but the causal factors for these differences remain unknown. Molecular biology studies are important to develop more effective alternative approaches to the treatment of this aggressive odontogenic tumour. Mutation status has a certain impact on diagnosis and prognosis.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For ameloblastoma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of ameloblastoma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease. 

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service