Alta Stomatology has an experienced antibody discovery technology team and a comprehensive antibody discovery technology platform. We utilize various methods such as hybridoma technology and phage display to provide antibody discovery and optimization services for clients from different species including human, mouse, rabbit, camel, and alpaca. Over the years, we have provided high-quality services to large pharmaceutical and biotechnology companies, earning the trust of our clients.

Phage Display Technology Platform

Phage display technology involves genetically engineering antibodies and linking their genes to bacteriophages. These antibodies are then displayed on the surface of the bacteriophage in the form of fusion proteins. By binding to target proteins, the screening of antibodies displayed on bacteriophages is achieved. With expertise in constructing and screening antibody libraries based on phage display, Alta Stomatology possesses extensive experience in antibody discovery and offers customized high-quality services for constructing phage display libraries. Additionally, we provide antibody development services for challenging targets such as G protein-coupled receptors (GPCRs) and ion channel-related proteins.

Advantages

• Ready-to-use human natural or synthetic libraries
• Customized immune libraries: human, mouse, rat, camel, llama, transgenic animals (sharing light chains), etc.
• Liquid-phase selection, solid-phase selection, and cell-based selection
• Epitope-based selection, which can better isolate functional lead molecules

Hybridoma Technology Platform

Alta Stomatology utilizes an advanced hybridoma-monoclonal antibody technology platform, employing hybridoma methods to offer antibody generation and discovery services. We also provide a variety of human antibody generation and discovery services. Through Alta Stomatology's hybridoma platform, we have successfully delivered multiple therapeutic antibody projects. Additionally, we have extensive experience in antibody discovery for G protein-coupled receptors (GPCRs) and other challenging targets.

Advantages

• Generating fully human antibodies using transgenic mice/rats.
• Employing multiple immunization strategies (DNA, peptides, proteins, cells, or their combinations) to tailor the immunization approach to the characteristics of the target.
• Enhancing immune responses through proprietary immunization protocols. Utilizing high fusion efficiency electroporation methods.
• High-throughput protein and cell screening platforms to support screening and antibody affinity ranking.
• Functional screening using hybridoma supernatants to obtain functional lead antibodies.

Bispecific Antibody Platform

Alta Stomatology's bispecific antibody platform is an innovative technology platform aimed at expanding the applications of bispecific antibodies. Based on state-of-the-art engineering designs, this platform accelerates the development process of antibody drugs for oral diseases and significantly reduces the cost of products. Our platform assembles nearly all monoclonal antibody sequences into bispecific structures, offering unique structural flexibility to establish various forms of bispecific antibodies with different valencies, such as 2, 3, or 4 binding sites.

Advantages

• Compatible with virtually any monoclonal antibody sequence
• Can be used in both symmetric and asymmetric forms simultaneously
• Utilizes the same purification methods as monoclonal antibodies
• Longer in vivo half-life
• Low immunogenicity

Laboratory Equipment

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service