Bone tissue requires complex systems to restore its standard shape and function. During bone repair, cells release cytokines, growth factors, and substances that cause inflammation in the area of the defect, attracting nearby stem cells to migrate, proliferate, and differentiate into bone-forming cells. When the body is unable to fully regenerate the damaged tissue, bioactive scaffolds can be used to assist in bone repair. Dental bone defects have become common diseases of the maxillofacial region, leading to impaired jaw function and causing significant psychological burdens to patients. Considering the prevalence of oral contamination and the aesthetic restoration of facial structures, current clinical treatment methods are limited, and unable to reconstruct structural integrity and regeneration, which stimulates the demand for cost-effective dental bone tissue engineering. To address this challenge, Alta Stomatology has established a cutting-edge bone tissue regeneration research platform. This platform integrates state-of-the-art technologies, innovative methodologies, and a multidisciplinary approach to accelerate the development of effective treatments for oral bone tissue defect-related ailments.

Our Fields of Oral Stem Cell Research

Biomaterials for Bone Regeneration

Alta Stomatology's research focuses on developing advanced biomaterials tailored for oral bone tissue regeneration applications. These biomaterials serve as scaffolds to support the growth of new bone tissue, providing a structural framework and promoting cellular adhesion, proliferation, and differentiation. By meticulously engineering the composition, porosity, and surface properties of these biomaterials, Alta Stomatology aims to optimize their biocompatibility, bioactivity, and degradation kinetics, ensuring superior performance in promoting oral bone tissue healing and regeneration. Cutting-edge techniques such as 3D printing, electrospinning, and nanotechnology are employed to fabricate biomaterials with precise architecture and tailored characteristics, enabling customization according to specific patient requirements.

Cell-Based Therapies for Bone Repair

Another key research focus of Alta Stomatology's bone tissue regeneration research platform revolves around cell-based therapies for oral bone tissue repair and regeneration. Stem cells, particularly mesenchymal stem cells (MSCs), hold immense potential in regenerative medicine due to their ability to differentiate into various cell types, including osteoblasts responsible for bone formation. Alta Stomatology explores innovative strategies to harness the regenerative capabilities of MSCs, such as optimizing culture conditions, enhancing cell survival and engraftment, and modulating their differentiation potential through growth factors, cytokines, and gene editing techniques. Furthermore, the platform investigates novel cell sources, including induced pluripotent stem cells (iPSCs) and stem cell-derived exosomes, to broaden the therapeutic repertoire and overcome limitations associated with conventional cell-based approaches.

Bioactive Molecules and Growth Factors

The identification and characterization of bioactive molecules and growth factors play a pivotal role in stimulating oral bone tissue regeneration and tissue repair. Alta Stomatology conducts extensive research to elucidate the signaling pathways and molecular mechanisms involved in oral bone tissue formation and remodeling, thereby identifying potential targets for therapeutic intervention. By harnessing the power of biologics, including bone morphogenetic proteins (BMPs), platelet-derived growth factors (PDGFs), and vascular endothelial growth factors (VEGFs), Alta Stomatology seeks to develop innovative strategies to enhance bone healing, accelerate tissue regeneration, and mitigate complications such as impaired vascularization and delayed wound healing.

What We Can Do

Laboratory Equipment

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service