Calcifying Cystic Odontogenic Tumor
Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for calcifying cystic odontogenic tumor. Calcifying cystic odontogenic tumor demonstrates considerable diversity in histopathology and clinical behavior. At Alta Stomatology, we're dedicated to offering one-stop services for calcifying cystic odontogenic tumor research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Histopathological images of CCOTs (Uchiyama Y, et al., 2012)
Research on Calcifying Cystic Odontogenic Tumor
Calcifying cystic odontogenic tumor first described by Gorlin in 1962, is a rare lesion representing 2% of all odontogenic pathological changes in the jaw. WHO in 2005, designated it as a tumor and renamed it as calcifying cystic odontogenic tumor (CCOT). CCOT is believed to be developmental in origin, derived from odontogenic epithelial remnants. It can occur at any age, with maximum incidence in the 2nd decade of life. It can occur centrally or peripherally, usually presenting as a painless swelling of jaw, equally affecting maxilla and mandible and more commonly involving anterior region than posterior.
Radiographic features of CCOT are variable. It may appear as unilocular radiolucency with well defined or ill defined margins or multilocular radiolucency in 5-13% of cases. Generally appears as unilocular lesion with a well defined margin. Radiopaque structures within the lesion either irregular calcifications or tooth like densities are present in about one third to one half of the cases. Teeth divergence and root resorption are common findings. It may produce expansion of cortical plates. Most cases vary from 2 to 4 cm in greatest diameter but lesion as large as 12 cm have been reported.
Our Products
QIAamp DNA FFPE Tissue Kit
FastGene Gel/PCR Extraction Kit
Beta-catenin
Hair Cortex Keratin
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on calcifying cystic odontogenic tumor and and its prevention and treatment. Genetic analysis is useful to support a diagnosis of CCOT. Through histological and immunohistochemical analysis of CCOT samples, we can gain an in-depth understanding of their morphological characteristics, cytological characteristics and molecular marker expression.
| Genetic Basis Analysis |
Pathological Research |
- DNA isolation and target-capture DNA sequencing
- PCR
- Direct sequencing
|
- Histological analysis
- Immunohistochemical analysis
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For calcifying cystic odontogenic tumor disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of calcifying cystic odontogenic tumor. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. |
| Laser Scanning Confocal Microscopy |
Laser scanning confocal microscopy (LSCM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. LSCM analysis is undertaken to further a better understanding of the nature of this peculiar lesion. |
References
- Jindal R, et al. Calcifying Cystic Odontogenic Tumor: Review with Discussion. GSTF J Adv Med Res. 2014; 1 (6).
- Yukimori A, et al. Genetic basis of calcifying cystic odontogenic tumors. PLoS One. 2017; 12(6):e0180224.
- Uchiyama Y, et al. Calcifying cystic odontogenic tumour: CT imaging. Br J Radiol. 2012; 85(1013):548-54.
For research use only. Not
intended for any clinical use.
Related Services
