Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for calcifying epithelial odontogenic tumor. Calcifying epithelial odontogenic tumor is a locally aggressive tumor consisting of strands and medullary patterns of squamous and clear cells that are often accompanied by spherical calcifications and amyloid-staining hyaline deposits. At Alta Stomatology, we're dedicated to offering one-stop services for calcifying epithelial odontogenic tumor research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Calcifying epithelial odontogenic tumor of a 38-year-old female patient (Misra SR, et al., 2013)

Research on Calcifying Epithelial Odontogenic Tumor

The calcifying epithelial odontogenic tumor (CEOT) is frequently referred to as the eponym "Pindborg tumor". It is rare, representing less than 1% of all odontogenic tumors. The lesion is locally aggressive with a biologic behavior similar to the common form of intraosseous ameloblastoma. It is thought to originate from the epithelial rests of the dental lamina or from the reduced enamel epithelium that overlies the crowns of the teeth. The neoplastic component of CEOT is reminiscent of epithelial and calcified structures normally found around the crowns of teeth. CEOT occurs as either a central (intraosseous) or peripheral (extraosseous) lesion.

Central CEOT occurs between the ages of 20 and 60 years, with a mean age of 40. Two thirds of the lesions are in the mandible. In both jaws most lesions occur in the molar area, followed in frequency by the premolar area. The remainder of the lesions is equally distributed throughout the rest of the jaws. The tumor presents as a slowly enlarging, painless mass. Nasal airway obstruction, epistaxis, and proptosis are sometimes experienced in the maxilla. Peripheral CEOT most commonly occurs in the anterior part of the mouth. It presents as a superficial soft tissue swelling of the gingiva in tooth-bearing and edentulous areas of the jaws.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on calcifying epithelial odontogenic tumor and and its prevention and treatment. The classical histopathological features of CEOT comprise sheets, cords and/or islands of polyhedral, neoplastic epithelial cells with well-defined cell borders and distinct intercellular bridges which may demonstrate pleomorphism and occasional mitosis. Detection of genetic factors that are involved in the molecular pathogenesis of odontogenic tumors helps us in targeted therapy.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For calcifying epithelial odontogenic tumor disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of calcifying epithelial odontogenic tumor. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease. 

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service