Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for cementoblastoma/true cementoma. Benign cementoblastoma (true cementoma) is a rare cementum-producing odontogenic tumor with distinctive clinical and radiographic characteristics. It attaches to the roots of posterior mandibular teeth and grows gradually, causing expansion of the involved jaw. At Alta Stomatology, we're dedicated to offering one-stop services for cementoblastoma/true cementoma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Typical case of cementoblastoma showing hyperchromatic, plump, active-looking cementoblasts rimming trabeculae and supported by delicate fibrovascular stroma (Almeida LY, et al., 2019)

Research on Cementoblastoma/True Cementoma

The benign cementoblastoma is also called as ‘true cementoma’. It is a rare odontogenic tumor representing less than 1% of all odontogenic tumors. Norberg initially described it in 1930. The WHO defines the benign cementoblastoma as "a neoplasm characterized by the formation of sheds of cementum like tissue which may contain a very large number of reversal line and may be unmineralized at the periphery of the mass or in the more active growth areas.

The benign cementoblastoma occurs most frequently under the age of the 25 years with slight predilection for males. Cementoblastoma can occur in both maxilla and the mandible. The mandible however, is involved three times more frequently than maxilla. The mandibular first permanent molar is the most frequently affected tooth. In humans, the cortical expansive action of the cementoblastoma has been occasionally associated with low-grade intermittent pain. Radiographically, the cementoblastoma is observed as a well-defined radiopaque mass surrounded by a radiolucent uniform halo, corresponding to the space of the periodontal ligament.

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on cementoblastoma/true cementoma and and its prevention and treatment. Determining the exact cause and understanding the pathogenesis of cementoblastoma are crucial in developing preventive measures. More research is needed on the microscopic features of cementoblastoma to improve diagnosis and understanding of its biological behavior.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For cementoblastoma/true cementoma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of cementoblastoma/true cementoma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease. 

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service