Alta Stomatology's chemical platform is equipped with state-of-the-art experimental apparatus that can assist customers in optimizing potential compounds for oral diseases, thereby enhancing their pharmacological properties. 

Proteolysis Targeting Chimera Technology

Proteolysis targeting chimera technology, as a novel protein degradation strategy, is increasingly being applied in drug development projects. With its innovative mechanism of action and novel molecular design, this technology can overcome some of the issues associated with traditional small molecule inhibitors, such as high dosage, side effects, and drug resistance. Alta Stomatology utilizes this technology to advance drug development for challenging oral diseases targets.

Peptide Technology

The peptide team at Alta Stomatology is composed of experienced synthetic personnel capable of efficiently developing target peptides for oral diseases, particularly in utilizing solid-phase and liquid-phase combination-modified peptide molecules (such as glycosylation modification), synthesizing ADC drug-linker conjugates, synthesizing small molecule-centered peptide dimers, and possessing rich experience in various areas of unique structural peptide drugs or intermediates. Additionally, we offer services such as peptide molecule labeling and stability testing experiments according to customer requirements.

Photocatalytic Reaction

Photoreaction technology is often used in drug development to synthesize biologically active small molecules. Alta Stomatology's chemistry team can utilize photocatalytic reactions to establish carbon-carbon bonds and carbon-hetero bonds in drug molecules for oral diseases, shortening the reaction pathway and significantly improving synthesis efficiency.

Deuterium Substitution and Isotope Modification

Deuterium-labeled compounds are widely used in modern drug research. The carbon-deuterium bond is more stable than the carbon-hydrogen bond, while having a smaller impact on the structure and bio-chemical properties of compounds. Deuterium-labeled compounds are often used to improve metabolic stability. The chemical team at Alta Stomatology has extensive experience in the synthesis of deuterium-labeled compounds, and can selectively deuterate small molecule structures and scale up oral disease candidate compounds to the hundred gram level.

Fluorescent Probes and Labeling

Fluorescent labeling is the process of attaching fluorescent compounds to biological molecules for experimental purposes such as visualization and quantification through fluorescence imaging. The chemical and biological team at Alta Stomatology has extensive experience in fluorescent probes and labeling, and has successfully used various fluorescent groups to label a variety of biological molecules in multiple projects, including proteins, peptides, antibodies, and nucleic acids.

Fluorine Chemistry

Due to the unique properties of fluorine atoms, selectively introducing fluorine atoms and fluorinated alkyl groups into oral disease drug molecules can significantly enhance the lipophilicity, bioavailability, and metabolic stability of bioactive molecules. The design and synthesis of fluorine-containing compounds have become an important part of drug development. The research team at Alta Stomatology has served multiple small molecule drug development projects and can efficiently design and synthesize routes for many structurally novel fluorinated compounds.

Macrocyclic Chemistry

The design of macrocyclic compounds is being used more in innovative drug development projects to expand the diversity of compound structures to enhance molecular binding capabilities and improve pharmacological properties. The chemistry team at Alta Stomatology has successfully synthesized a variety of structurally unique macrocyclic compounds in past projects, which can help clients optimize the pharmacological properties of oral disease drugs.

Laboratory Equipment