Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for chronic focal sclerosing osteomyelitis. Condensing osteitis represents an asymptomatic change in osseous structure presumed to be the response to a long-standing and low-grade inflammatory stimulus from an inflamed or necrotic pulp. At Alta Stomatology, we're dedicated to offering one-stop services for chronic focal sclerosing osteomyelitis research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Condensing osteitis in two patients (Rodrigues P, et al., 2019)

Research on Chronic Focal Sclerosing Osteomyelitis/Condensing Osteitis

Condensing Osteitis or Focal Sclerosing Osteomyelitis is characterized by the formation of periapical sclerotic bone. It consists of a focalized osseous reaction leading to bone growth resulting from inflammatory stimuli or local low intensity trauma. Although described as a result of periapical of pulp inflammation and /or infection, it's also observable in vital teeth as a consequence of occlusal trauma and, thus, aetiologically not associated with pulp aggression, which may lead to misdiagnosis.

Clinically, in most cases, there is absent or mild pain, no lymphadenopathy and no cortical expansion. Traumatic malocclusion may play a role in the pathogenesis of condensing osteitis. Radiologically, these radiopaque lesions are associated with previously restored teeth or teeth undergoing trauma mostly in the molar region of the mandible. Eighty-five percent of chronic focal sclerosing osteomyelitis cases occur mainly in the mandible, especially in the lower first molar region. Condensing osteitis is less frequent in the maxilla probably due to lower cortical thickness and abundant irrigation. Its radiological appearance remains even with exodontia of the involved tooth.

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on chronic focal sclerosing osteomyelitis and and its prevention and treatment. In lesions of condensing osteitis, histopathology plays a major role in determining the final diagnosis and subsequent course of treatment.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For chronic focal sclerosing osteomyelitis disease, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of chronic focal sclerosing osteomyelitis. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of jaw disease.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service