Chronic Suppurative Osteomyelitis
Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for chronic suppurative osteomyelitis. The main cause of chronic suppurative osteomyelitis of the jaws is odontogenic infections, which might occur as a complication of dental extractions, maxillofacial trauma, or irradiation of the facial skeleton. The clinical findings of this disease were characterized by the presence of pus, fistula, and sequestration. At Alta Stomatology, we're dedicated to offering one-stop services for chronic suppurative osteomyelitis research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Orthopantogram of chronic suppurative osteomyelitis (Vora, MM, et al., 2014)
Research on Chronic Suppurative Osteomyelitis
Osteomyelitis is an inflammatory condition of bone and bone marrow, which has a tendency to involve the adjacent cortex, periosteum, and soft tissue. Chronic supperative osteomyelitis of the jaw (CSOJ) is a persistent inflammatory process in the mandible or the maxilla presenting with necrosis of mineralized and marrow tissues, suppuration, resorption, sclerosis, and hyperplasia. This is mainly triggered by inoculation of micro-organisms into the jawbones as a result of trauma or odontogenic infection. Some other reasons such as steroids, chemotherapeutic agents, and biphosphonates such as alendronic acid are also linked to CSOJ.
Clinical findings in chronic mandibular osteomyelitis include local pain, fever, swelling, purulent discharge, intraoral and skin fistula, unhealed soft tissue in the oral cavity, neuropalsy in the involved area, pathologic fracture, and trismus. The acknowledged and effectual treatment for CSOJ is a combination of antimicrobial therapy and surgery consisting of incision and drainage, debridement or sequestrectomy. CSOJ remains a potentially lethal infection because of the possibility of life-threatening complications, such as sepsis, brain abscess, suppurative jugular thrombophlebitis, carotid erosion, and respiratory obstruction.
Our Products
Vascular Endothelial Growth Factor A (VEGF-A)
Transforming Growth Factor β1 (TGF-β1)
Alkaline Phosphatase (ALP)
S. aureus
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on chronic supperative osteomyelitis and and its prevention and treatment. Histopathology is crucial for understanding pathological processes accompanying diseases. To better understand chronic supperative osteomyelitis, it is important to carry out careful histopathological examinations. Accurate microbiological diagnosis is a cornerstone in management of osteomyelitis.
| Histological and Immunohistological Analysis |
Microbiological Diagnosis |
- Hematoxylin and eosin(H&E) staining
- Immunohistochemistry (IHC) staining
- Masson's trichrome (MT) staining
|
- Blood testing
- PCR
- Bacterial pathogen detection
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For chronic supperative osteomyelitis diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of chronic supperative osteomyelitis. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of jaw disease.
| Diagnosis Methods |
Description |
| Micro Computed Tomography |
Micro-CT analysis tools provide a highly reproducible methodology with qualitative and quantitative assessment of bone microstructure. Micro-CT is considered to be a gold standard method for assessing mineral density, bone morphology, and bone micro-architecture under various pathological conditions. |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the jaw, enabling our experts to accurately identify lesions occurring in the jaw. |
| Cone Beam Computed Tomography (CBCT) |
Cone beam computed tomography (CBCT) is a CT technique that uses far less radiation than conventional CT and captures multiple views of the patient in a single 360° rotation. The information thus obtained is then processed and reconstructed in different planes (multiplanar reconstruction) and, if necessary, three-dimensionally as well. |
References
- Chen L, et al. Risk factors of recurrence and life-threatening complications for patients hospitalized with chronic suppurative osteomyelitis of the jaw. BMC Infect Dis. 2013; 13: 313.
- Koorbusch GF, et al. How can we diagnose and treat osteomyelitis of the jaws as early as possible? Oral Maxillofac Surg Clin North Am. 2011; 23(4):557-67.
- Vora MM, et al. SURGICAL MANAGEMENT OF CHRONIC SUPPURATIVE OSTEOMYELITIS OF MANDIBLE IN AN ELDERLY PATIENT A CASE REPORT. International journal of current research and review. 2010; 6: 58-64.
For research use only. Not
intended for any clinical use.
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