| Synonym(s): |
γ-Secretase inhibitor XX, (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide; DBZ; Dibenzazepine; GSI-XX, N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide; YO-01027 |
| Description: |
Deshydroxy LY-411575 is a cell-permeable inhibitor of γ-secretase and Notch processing. It reduces brain and plasma Aβ40 levels by approximately 72% in Tg2576 mutant APP transgenic mouse models. Additionally, it effectively inhibits Notch processing, displaying an IC50 of 1.7 nM in SupT1 cells.
LY411575 also prevents the SPP (signal peptide peptidase)-dependent cleavage of the hepatitis C virus (HCV) core protein. |
| Application: |
Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment. |
| Storage: |
−20°C |
| CAS No.: |
209984-56-5 |
| Molecular Weight: |
463.48 |
| Formula: |
C26H23F2N3O3 |
| Appearance: |
Powder |
| Color: |
White to beige |
| InChI: |
1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1 |
| InChI key: |
QSHGISMANBKLQL-OWJWWREXSA-N |
| Quality Level: |
100 |
| Storage Class Code: |
11 - Combustible solids |
| Solubility: |
DMSO: 15 mg/mL, clear |
| Assay: |
≥ 98% (HPLC) |
| Optical Activity: |
[α]/D -128.0 to -154.0°-0.25 in methanol |
