Developmental and Reproductive Toxicology
Alta Stomatology is a company specializing in the research and development of medications for oral diseases. Our research team is led by drug toxicity experts with years of experience, supported by a professional technical team. We possess state-of-the-art experimental instruments such as fully automated sperm analyzers, imaging endoscopes, Leica microscopes, and others, enabling us to provide comprehensive services for the developmental and reproductive toxicity research of oral disease drugs. If you have any needs, please feel free to contact us.
Our Services
Fertility and Early Embryonic Development
Fertility and early embryonic development studies are essential for determining the effects of oral disease drugs on reproductive performance and the development of embryos. At Alta Stomatology, we offer a range of services to evaluate fertility endpoints, such as estrous cycles, sperm motility and sperm morphology and staging, reproductive organ exams, etc.
| External genitalia |
Reproductive organ exams |
| Reproductive performance |
Biochemical and hormonal parameters |
| Sperm motility |
Sperm morphology and staging |
| Estrus and menstrual cycle determination |
Testis volume and biopsy |
| Prostate volume and biopsy in nonhuman primates |
|
Embryo-Fetal Development
The embryo-fetal development studies at Alta Stomatology focus on assessing the effects of oral disease drug candidates on embryo development and fetal growth. These studies are critical for determining the potential risks of our drugs on pregnancy outcomes and offspring health.
| Maternal toxicity |
Embryotoxicity |
| Fetotoxicity |
Teratogenicity (fetal external evaluation, fetal soft tissue evaluation, fetal skeletal evaluation) |
Prenatal and Postnatal Development
Our prenatal and postnatal development studies evaluate the effects of oral disease drug candidates on the developing fetus and newborn offspring. These studies are essential for assessing the long-term effects of drugs on postnatal growth, organ development, and overall health.
| Sensory functions |
Learning and memory |
| Motor activity |
Reproductive function |
Species
Rat, mouse, rabbit
Route of Administration
| Oral: gavage, dietary, drinking water |
Subcutaneous |
| Intravenous |
Intramuscular |
Why Choose Alta Stomatology?
With a seasoned team of toxicologists, pharmacologists, and other science professionals, we bring to the table unmatched expertise in reproductive and developmental toxicology.
- State-of-the-Art Facilities
Alta Stomatology is equipped with cutting-edge facilities to conduct comprehensive developmental and reproductive toxicology studies. Our state-of-the-art laboratories and equipment ensure accurate and reliable results.
At Alta Stomatology, we understand that every drug development program is unique, and we tailor our developmental and reproductive toxicity services to meet the specific needs of each client. Whether our clients are developing a new oral disease drug or seeking to expand the safety profile of an existing drug, we can provide customized solutions to support their goals.
At Alta Stomatology, safety is our top priority. We are dedicated to developing safe and effective drugs for oral diseases, and our developmental and reproductive toxicology services help us ensure the safety of our drug candidates for individuals of reproductive age, pregnant women, and newborns.
For research use only. Not
intended for any clinical use.
