Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for erythroplasia. Erythroplasia is defined as any lesion of the oral mucosa that presents as bright red velvety plaques which cannot be characterized clinically or pathologically as any other recognizable condition. At Alta Stomatology, we're dedicated to offering one-stop services for erythroplasia/erythroplastic lesion research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Erythroplakia on the soft palate (Villa A, et al., 2011)

Research on Erythroplasia/Erythroplastic Lesion

Erythroplasia, known as erythroplakia, is an atypical, painless, slow-growing red patch or lesion on the mucous membranes of the oral cavity. These lesions may be flat or raised, have well-defined margins, and are most commonly found on the tongue or floor of the mouth alongside leukoplakia lesions. Erythroplakia is characterized by decreased epithelial cells and increased vascularization, which gives it its red color and increased friability. Erythroplakia is a fiery red patch on the oral mucosa that cannot be characterized clinically or pathologically as any other definable lesion. This is primarily a clinical diagnosis and, as such, is a diagnosis by exclusion of other defined lesions on a biopsy. A spectrum of histopathological changes has been associated with this diagnosis.

These lesions should be diagnosed early to prevent the risk of malignant transformation if left untreated, in which treatment would be difficult. Erythroplakia may occur without pain or other symptoms and, therefore, may go unnoticed. The most common etiology includes smoking, alcohol, and areca nut chewing. A wide variety of treatment modalities are available including topical and systemic corticosteroids, retinoids, and surgical intervention.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on erythroplasia and and its prevention and treatment. Through immunohistochemistry analysis, the protein expression of some genes in the tissue can detect erythroplasia and its severity. Exploring the expression patterns of these genes plays an important role and significance in the process of oral carcinogenesis. Through histological analysis, the erythroplasia is tested for the presence of hyperkeratosis, low-grade (mild or moderate) dysplasia, or high-grade (severe dysplasia).

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For erythroplasia diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of erythroplakia. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of oral mucosa disease.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service