Exosomes are membrane vesicles secreted by cells, with a diameter of 30-150 nm, characterized by a phospholipid bilayer structure. They contain a variety of substances, including proteins, miRNAs, mRNAs, lncRNAs, DNA fragments, cytokines, and lipids, carrying a wealth of biological information. Studies have found that almost all types of cells can secrete exosomes, which are widely present in tissue fluids, blood, saliva, urine, cerebrospinal fluid, and breast milk.

In recent years, the significant role of exosomes in intercellular material exchange and signal transmission has received increasing attention, making them a new research hotspot. As a means of intercellular communication, exosomes play important roles in various physiological and pathological processes such as growth and development, infection, and tumor occurrence and metastasis. Alta Stomatology is a leading oral disease research company, that can provide a one-stop exosome development and testing services, we can leverage the latest technology to study oral disease mechanisms, progression, and potential treatments. Additionally, their carrier properties make them ideal candidates for use as biological materials in targeted oral disease drug delivery and gene therapy. If you have any needs, please feel free to contact us.

Our Services

Exosomes Development Service

At Alta Stomatology, our Exosomes Development Service is designed to assist researchers in developing tailored exosomes for their specific needs.

Custom Exosome Production: We offer custom exosome production from various cell types, including stem cells, immune cells, and tumor cells. Our optimized protocols ensure high yield and purity, tailored to meet specific research needs.

Optimization of Culture Conditions: Our experts optimize cell culture conditions to maximize exosome yield and functionality, ensuring consistency and reproducibility in your research.

Isolation and Purification of Exosomes

We employ state-of-the-art techniques to isolate and purify exosomes from a variety of biological samples, including saliva, blood, and tissue fluids. Our methods ensure high yield and purity, providing researchers with reliable and consistent exosome preparations for downstream analyses.

Our Methods

Characterization of Exosomes

Nanoparticle Tracking Analysis (NTA): To determine the size distribution and concentration of exosomes.

Transmission Electron Microscopy (TEM): For detailed imaging and morphological assessment.

Western Blotting and Flow Cytometry: To analyze the protein composition and surface markers of exosomes.

RNA and DNA Profiling: To identify and quantify nucleic acids contained within exosomes, including miRNA, mRNA, and DNA fragments.

Exosomes Functional Studies

We offer a variety of functional assays to investigate the biological activities of exosomes, such as:

Cellular Uptake Studies: To assess how exosomes interact with target cells.

Signal Transduction Pathways: To explore the molecular mechanisms by which exosomes influence recipient cells.

In Vitro and In Vivo Models: To study the effects of exosomes on cell proliferation, differentiation, migration, and other relevant biological processes.

Exosome-Based Biomarker Discovery

Alta Stomatology is dedicated to identifying and validating exosome-derived biomarkers for early diagnosis and prognosis of oral diseases. Our biomarker discovery services include:

High-throughput Screening: To identify candidate biomarkers from large-scale proteomic and genomic datasets.

Bioinformatics Analysis: To analyze and interpret complex data, identifying patterns and potential clinical relevance.

Validation Studies: To confirm the reliability and specificity of candidate biomarkers in independent cohorts.

Why Choose Alta Stomatology?

• Advanced Technology

Alta Stomatology employs the latest exosome extraction and identification technologies to provide efficient and reliable services. Our advanced methodologies ensure the accurate isolation and characterization of exosomes, laying a solid foundation for downstream analyses.

• High-Quality Data

Our professional team, comprising experienced scientists and bioinformaticians, ensures that every aspect of data analysis and interpretation is conducted with the utmost precision.

• Rapid Delivery

Our efficient experimental processes and operational expertise enable us to deliver results in a timely manner, meeting even the most stringent time requirements. We understand the importance of quick turnaround times in research and development and strive to meet these needs without compromising quality.

• Confidentiality and Reliability

We strictly protect customer samples and data information, maintaining confidentiality and ensuring secure handling of all materials. Our commitment to confidentiality and reliability builds trust with our clients.