General toxicology tests are conducted to study the toxicity of drugs on animals. These studies aim to determine the relationship between different dose levels of administration and adverse reactions, as well as to identify any potential target organs or functions that may be affected. Alta Stomatology is a company dedicated to the development of drugs for oral diseases. We can provide comprehensive general toxicology services tailored to client needs and regulatory requirements, including tolerance studies, dose exploration, acute toxicity tests, etc. We can customize dose toxicity studies and testing protocols based on the characteristics of oral disease drugs and customer requirements to evaluate predictive toxicology of oral disease drugs, acute toxicity studies for immediate adverse effects post-exposure, and chronic toxicology studies to assess long-term impacts. If you have any needs, please feel free to contact us.
Our Services
Single-Dose Toxicity Studies (Acute Toxicity)
Single-dose toxicity studies are conducted to evaluate the adverse effects of a substance following a single exposure. These studies aim to determine the maximum tolerated dose (MTD) and identify any potential toxic effects that may occur shortly after administration. At Alta Stomatology, our team of experienced toxicologists designs and executes comprehensive single-dose toxicity studies in accordance with regulatory guidelines to ensure the safety of our oral disease drug candidates.
Repeated-Dose Toxicity Studies (Subacute, Subchronic, and Chronic)
Repeated-dose toxicity studies are conducted to assess the effects of prolonged exposure to an oral disease drug over a specified period. These studies provide valuable information on the potential cumulative toxicity, organ damage, and systemic effects of an oral disease drug candidate. At Alta Stomatology, we offer a range of repeated-dose toxicity studies. These studies primarily encompass subacute (less than one month), subchronic (one to three months), and chronic (beyond three months) testing. Repeated-dose studies provide critical information on the toxic effect over time, helping identify target organs for toxicity, the potential for accumulation, and the reversibility of observed adverse effects.
Dose Tolerance Studies
The dose tolerance studies we conduct aim to facilitate the selection of safe and effective doses by investigating the highest dose that doesn't produce unacceptable side effects. This assists in establishing the maximum tolerable dose and the potential range for therapeutic application. Furthermore, it aids in dose adjustment for special populations, such as the elderly, children, or patients with renal or liver impairment.
Dose Exploration Trials
Dose exploration trials are conducted to identify the optimal dose range for an oral disease drug candidate, balancing efficacy with safety considerations. These trials involve administering different doses of the drug to evaluate its therapeutic effects and potential toxicity in preclinical models. At Alta Stomatology, we conduct dose exploration trials with meticulous attention to detail. These studies aim to determine the dose-response relationship and assess the efficacy and safety profiles across a range of doses.
Experimental Models
Rodents (rats, mice, guinea pigs, etc.)
Non-rodents (rabbits, dogs, monkeys, miniature pigs, etc.)
Why Choose Alta Stomatology?
With a team of highly skilled toxicologists, pharmacologists, and researchers, Alta Stomatology brings years of experience in conducting general toxicology studies for oral disease drug candidates. Our multidisciplinary approach ensures comprehensive evaluation and interpretation of toxicological data, guiding decision-making throughout the drug development process.
We offer customized toxicology study designs tailored to the specific needs and requirements of our clients. Whether you need a single-dose toxicity study or a comprehensive evaluation of chronic toxicity, we can develop a study protocol that meets your objectives.
- Commitment to Safety and Compliance
At Alta Stomatology, we adhere to stringent regulatory guidelines and industry best practices to ensure the highest standards of safety and compliance in all our toxicology studies. By employing state-of-the-art facilities and methodologies, we deliver reliable and reproducible data.
- Collaborative Approach and Transparent Communication
At Alta Stomatology, we believe in fostering collaborative partnerships built on trust and transparency. From project initiation to final report delivery, we maintain open lines of communication with our clients, providing regular updates and soliciting feedback to ensure alignment with their expectations and goals. Our responsive and proactive approach enables us to adapt to evolving project needs and deliver results that exceed expectations.
For research use only. Not
intended for any clinical use.
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