Hit identification is a critical step in the drug discovery process that involves screening large libraries of compounds to identify potential drug candidates that show activity against a specific target. At Alta Stomatology, we offer a range of hit identification services that leverage advanced technologies and expertise to accelerate the drug discovery process for oral health conditions. Our services include high throughput screening, fragment-based screening, ASMS screening, virtual screening, and DNA-encoded libraries (DEL). If you have any needs, please feel free to contact us.
Our Services
High Throughput Screening (HTS)
HTS is a powerful method for screening large libraries of compounds against a target of interest. At Alta Stomatology, we have state-of-the-art automated screening platforms that can rapidly test thousands of compounds for their activity against oral disease targets. Our HTS service allows for the efficient identification of lead compounds with desirable pharmacological properties, setting the stage for further optimization.
Fragment-Based Screening
Fragment-based screening is a highly sensitive method that involves screening small molecule fragments. By screening libraries of small molecular fragments, we can identify initial hits that interact with target proteins. These fragments serve as building blocks for the development of more potent and selective oral disease drug candidates through fragment evolution and elaboration strategies.
Affinity Selection Mass Spectrometry (ASMS) Screening
Affinity selection mass spectrometry (ASMS) is a powerful method for screening compound libraries based on their binding affinity to a target. At Alta Stomatology, we utilize ASMS screening to identify hits that bind to specific oral disease targets with high affinity, providing valuable informations into the mechanism of action of potential drug candidates.
Virtual Screening
Virtual screening involves the use of computer algorithms to screen compound libraries for potential drug candidates. By leveraging computational techniques and molecular modeling, Alta Stomatology can screen virtual compound libraries against target structures to predict potential binding interactions. This in silico approach accelerates the identification of hit compounds, complementing experimental screening efforts and enhancing the overall efficiency of the oral disease drug discovery process.
DNA-Encoded Libraries (DEL)
DNA-encoded libraries are large collections of small molecule compounds that are synthesized on a DNA scaffold. By encoding chemical compounds with unique DNA tags, Alta Stomatology can screen vast libraries of compounds in parallel, enabling the rapid identification of hits with desired biological activities.
Why Choose Alta Stomatology?
Alta Stomatology boasts a team of highly skilled scientists and researchers with extensive experience in oral disease drug discovery. Our interdisciplinary approach combines expertise in molecular biology, pharmacology, and computational chemistry, ensuring comprehensive support throughout the hit identification process.
- State-of-the-Art Facilities
We operate state-of-the-art laboratories equipped with cutting-edge instrumentation and automation systems. Our facilities are designed to facilitate high-throughput screening, fragment-based screening, ASMS analysis, virtual screening, and DEL synthesis, enabling efficient and streamlined hit identification workflows.
At Alta Stomatology, we understand that every drug discovery project is unique. That's why we offer tailored hit identification solutions to meet the specific needs and objectives of our clients. Whether it's screening large compound libraries, exploring fragment-based approaches, or utilizing computational modeling, we adapt our services to align with project requirements.
Our hit identification services are conducted with the highest standards of quality and rigor. We prioritize accuracy and reproducibility in our screening assays to ensure the identification of reliable hits for oral disease targets.
For research use only. Not
intended for any clinical use.
