| Target: |
IL-6 (Interleukin 6) |
| Binding Specificity: |
AA 101-150 |
| Reactivity: |
Mouse, rat |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
ELISA, immunofluorescence (cultured cells) (IF (cc)), immunofluorescence (paraffin-embedded sections) (IF (p)), immunohistochemistry (frozen sections) (IHC (fro)), immunohistochemistry (paraffin-embedded sections) (IHC (p)), western blotting (WB) |
| Purification: |
Purified by protein A. |
| Immunogen: |
KLH conjugated synthetic peptide derived from mouse IL-6. |
| Isotype: |
IgG |
| Format: |
Liquid |
| Concentration: |
1 μg/μL |
| Buffer: |
0.01 M TBS (pH7.4) with 1% BSA, 0.03% proclin300 and 50% glycerol. |
| Precaution of Use: |
This product contains a poisonous and hazardous substance, which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles. |
| Storage: |
- 20°C |
| Storage Comment: |
Store at - 20°C for one year. |
| Expiry Date: |
12 months |
| Alternative Name: |
IL-6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Cytokine boasts a broad spectrum of biological functions. It stands as a potent trigger of the acute phase response and holds pivotal importance in steering B-cells toward their final transformation into Ig-secreting cells. Moreover, it intricately participates in the differentiation of lymphocytes and monocytes, exerting its influence on various cell types including B-cells, T-cells, hepatocytes, hematopoietic progenitor cells, and CNS cells. Crucially, it's indispensable for the generation of T(H)17 cells and doubles as a myokine, released into the bloodstream post-muscle contraction. This release aims to enhance fat breakdown and mitigate insulin resistance. However, it's worth noting its potential role in fostering the growth of myeloma and plasmacytoma, while also orchestrating nerve cell differentiation. |
