| Target: |
IL-6 (Interleukin 6) |
| Binding Specificity: |
AA 110-185 |
| Reactivity: |
Human, mouse, rat |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
ELISA, immunofluorescence (cultured cells) (IF (cc)), immunofluorescence (paraffin-embedded sections) (IF (p)), immunohistochemistry (frozen sections) (IHC (fro)), immunohistochemistry (paraffin-embedded sections) (IHC (p)), western blotting (WB) |
| Purification: |
Purified by protein A. |
| Immunogen: |
KLH conjugated synthetic peptide derived from human IL-6. |
| Isotype: |
IgG |
| Format: |
Liquid |
| Concentration: |
1 μg/μL |
| Buffer: |
0.01 M TBS (pH7.4) with 1% BSA, 0.03% proclin300 and 50% glycerol. |
| Precaution of Use: |
This product contains a poisonous and hazardous substance, which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freeze/thaw cycles. |
| Storage: |
- 20°C |
| Storage Comment: |
Store at - 20°C for one year. |
| Expiry Date: |
12 months |
| Alternative Name: |
IL-6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
Cytokine boasts a diverse array of biological functions, serving as a potent initiator of the acute phase response. It holds a pivotal role in guiding B-cells toward their final differentiation into Ig-secreting cells and plays a crucial part in the differentiation of lymphocytes and monocytes. Its effects span across various cell types including B-cells, T-cells, hepatocytes, hematopoietic progenitor cells, and central nervous system cells. This cytokine is indispensable for the development of T(H)17 cells and doubles as a myokine. Upon muscle contraction, it is released into the bloodstream, catalyzing the breakdown of fats and enhancing insulin sensitivity. Moreover, it promotes the growth of myeloma and plasmacytoma while also stimulating the differentiation of nerve cells. |
