| Target: |
IL-6 (Interleukin 6) |
| Binding Specificity: |
AA 195-212, C-Term |
| Reactivity: |
Human |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
Western blotting (WB) |
| Purpose: |
Rabbit IgG polyclonal antibody for Interleukin-6(IL6) detection. Tested with WB in Human. |
| Sequence: |
LRSFKEFLQS SLRALRQM |
| Characteristics: |
Rabbit IgG polyclonal antibody for interleukin 6 (interferon, beta 2)(IL6) detection. Tested with WB in human.
Gene name: interleukin 6 (interferon, beta 2).
Protein name: interleukin-6. |
| Purification: |
Immunogen affinity purified. |
| Immunogen: |
A synthetic peptide corresponding to a sequence at the C-terminus of human IL-6(195-212aa LRSFKEFLQSSLRALRQM). |
| Isotype: |
IgG |
| Format: |
Lyophilized |
| Concentration: |
500 μg/mL |
| Reconstitution: |
Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL. |
| Buffer: |
Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg thimerosal, 0.05 mg sodium azide. |
| Precaution of Use: |
This product contains sodium azide and thimerosal (merthiolate): poisonous and hazardous substances which should be handled by trained staff only. |
| Handling Advice: |
Avoid repeated freezing and thawing. |
| Storage: |
4°C, - 20°C |
| Storage Comment: |
At - 20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at - 20°C for a longer time. |
| Expiry Date: |
12 months |
| Alternative Name: |
IL6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
The IL6 gene in humans encodes Interleukin-6 (IL-6), a protein with dual roles as both a pro-inflammatory and anti-inflammatory cytokine. T cells and macrophages secrete IL-6 to trigger immune responses, particularly in cases of trauma like burns or tissue damage that leads to inflammation. IL-6 plays a crucial role in inducing fever and the acute phase response. Additionally, IL-6 is vital for the growth of hybridomas and is commonly included in cloning media such as briclone. Bowcock et al. (1988) identified the IL6 gene on chromosome 7p21, while Sutherland et al. (1988) mapped it to chromosome 7p15 using in situ hybridization and Southern blot analysis of mouse-human hybrid cell lines. |
