| Target: |
IL-6 (Interleukin 6) |
| Reactivity: |
Human, mouse, rat |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
This IL-6 antibody is un-conjugated |
| Application: |
Immunohistochemistry (IHC) |
| Characteristics: |
Polyclonal antibody |
| Purification: |
Affinity purification |
| Immunogen: |
Recombinant fusion protein of human IL6 (NP_000591.1). |
| Isotype: |
IgG |
| Format: |
Liquid |
| Concentration: |
1 mg/mL |
| Buffer: |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Precaution of Use: |
This product contains sodium azide: a poisonous and hazardous substance which should be handled by trained staff only. |
| Handling Advice: |
Avoid freeze / thaw cycles. |
| Storage: |
- 20°C |
| Storage Comment: |
Store at - 20°C. |
| Alternative Name: |
IL6 |
| Synonyms: |
BSF2, HGF, HSF, IFNB2, IL-6, Il-6, ILg6, Ifnb2, il6, CHIL-6, interleukin 6, interleukin-6, IL6, Il6, il-6, IL-6. |
| Background: |
This gene is responsible for producing a cytokine that plays vital roles in inflammation regulation and the maturation process of B cells. Moreover, the protein it encodes acts as a natural fever-inducer, triggering elevated body temperature in individuals with autoimmune conditions or infections. Its production primarily occurs at sites experiencing acute or chronic inflammation, where it is released into the bloodstream. Upon binding to the interleukin 6 receptor, alpha, it initiates a transcriptional inflammatory response. Dysfunctions in this gene have implications in various inflammation-related diseases, such as susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Additionally, alternative splicing leads to the generation of multiple transcript variants. |
