Immunotoxicology

Immunotoxicology

Immunotoxicity involves the study of a drug's ability to damage humoral or cellular immune responses, resulting in immunosuppression or causing unnecessary tissue damage (such as in over-sensitivity responses, autoimmunity, or chronic inflammation). Therefore, monitoring the potential immunotoxic effects is of significant importance in the development of oral disease drugs, enabling the implementation of appropriate strategies during the early stages of development. Alta Stomatology is a company dedicated to the R&D of oral disease drugs, and we can provide clients with comprehensive toxicity testing services to detect, quantify, and interpret the potential adverse effects of oral disease drugs on the immune system. We offer a range of testing methods, including in vitro, in vivo, and ex vivo models, to help you evaluate the immune structure and function of oral disease drugs, and identify potential risks early in the drug development process. If you have any needs, please feel free to contact us.

Immunotoxicology

Our Services

At Alta Stomatology, our experienced team of scientists works closely with clients to design customized pre-clinical immunotoxicology studies tailored to their specific needs and requirements. We employ a variety of in vitro assays to assess the immunotoxic potential of drug candidates. These assays include but are not limited to cytokine profiling, lymphocyte proliferation assays, and phagocytosis assays. By utilizing state-of-the-art techniques and methodologies, we can accurately evaluate the impact of substances on immune cell function and cytokine release.

In addition to in vitro assays, we conduct in vivo studies using animal models to further investigate the immunotoxic effects of drug candidates. Through these studies, we can assess parameters such as immune cell populations, antibody production, and hypersensitivity reactions to evaluate the overall immunotoxic profile of the tested compounds.

White Blood Cell Differential Count Globulin Levels and A/G Ratios
Lymphoid Organ Weight Lymphoid Tissue Histopathology
T-Cell Dependent Antigen Response (TDAR) Plaque Forming Cell Assay (PFC)
Anti-KLH IgM ELISA Test Lymphocytes Sub-Set FACS Analysis
Natural Killer (NK) Cell Assay Cytotoxic T Lymphocyte (CTL) Assay
T Cell Proliferation Assay Macrophage/Neutrophil Function
Phagocytosis/Respiratory Burst Immunophenotyping Analysis
In Vitro Whole Blood and PBMC Immunomodulation Assays Hypersensitivity Testing

Why Choose Alta Stomatology?

  • Expertise and Experience

Unlike generic contract research organizations, Alta Stomatology specializes exclusively in oral disease drug development. Alta Stomatology's team consists of world-class immunologists, toxicologists, and clinical scientists who work cooperatively to provide the most precise and reliable immunotoxicology results.  

  • State-of-the-Art Facilities

Alta Stomatology is equipped with advanced laboratory facilities to support a wide range of immunotoxicology assays. Our state-of-the-art equipment allows us to perform high-quality tests with precision and accuracy, delivering reliable results to our clients.

  • Customized Solutions

At Alta Stomatology, we understand that every drug candidate is unique, with its own set of immunotoxicology challenges. We work closely with clients to develop customized study protocols that address their specific research questions and compliance requirements. Our personalized approach ensures that each study is tailored to meet the client's needs and objectives.

  • Regulatory Compliance

Oral disease drug development is a highly regulated industry, with strict guidelines and requirements for assessing the safety of new drugs. Alta Stomatology is committed to upholding the highest standards of regulatory compliance in its immunotoxicology testing services. We follow Good Laboratory Practices (GLP) and adhere to all relevant regulations to ensure the integrity and reliability of our data.

For research use only. Not intended for any clinical use.
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