Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for keratocystic odontogenic tumor. Keratocystic odontogenic tumor is defined as a benign unicystic or multicystic intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium that is noted for its locally aggressive nature and capacity for recurrence. At Alta Stomatology, we're dedicated to offering one-stop services for keratocystic odontogenic tumor research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Variations of keratocystic odontogenic tumor histopathological features (zevedo RS, et al., 2012)

Research on Keratocystic Odontogenic Tumor

Keratocystic odontogenic tumor (KCOT), formerly referred to as odontogenic keratocyst, is a benign neoplasm of odontogenic origin which may present an aggressive and infiltrative behavior leading to high recurrence rates. KCOTs represent about 10% of all jaw cysts. As a matter of fact, scientific data on incidence of KCOTs are very heterogeneous, which actually reflect differences in diagnostic criteria and sample selection in individual studies. Around 40% to 60% of all KCOTs are diagnosed in patients in their 2nd and 3rd decade of life. KCOTs are more frequent in men compared to women.

It is widely accepted that KCOTs originate from odontogenic epithelium. Remnants of dental lamina, and also proliferations of the basal cell layer of oral epithelium, are considered as possible sources of epithelial cells which may proliferate to form a KCOT. Regardless of the source of epithelial cells, the etiology of KCOTs is strongly related to genetic factors, in particular to mutation of tumor-suppressor PTCH gene. Lack of PTCH function results in increased transcription of genes responsible for cell proliferation and, ultimately, in tumor formation.

Our Products 

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on keratocystic odontogenic tumor and and its prevention and treatment. Molecular testing will improve our understanding of odontogenic tumor pathogenesis. Improved understanding of mutations in odontogenic tumors may clarify classification schema and elucidate targets for novel therapies.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For keratocystic odontogenic tumor disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of keratocystic odontogenic tumor. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease. 

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service