The optimization of lead antibody molecules is a crucial step in the process of discovering antibody drugs. At Alta Stomatology, a company dedicated to oral disease drug development, our team of experts combines extensive knowledge in molecular biology, immunology, stomatology, and diagnostics. This allows us to provide comprehensive services for the optimization and evaluation of lead antibody molecules, covering monoclonal antibodies (mAb), bispecific antibodies (bsAb), and multispecific antibodies. If you have any requirements, please feel free to contact us without hesitation.

Our Services

Our core competency lies in lead antibody optimization, a critical phase in the development of therapeutics targeting oral diseases. We offer a comprehensive suite of services that encompass every aspect of the lead optimization process, ensuring the creation of highly effective antibodies tailored to specific oral health challenges.

Affinity Maturation

We specialize in enhancing the binding affinities of lead antibodies using advanced techniques such as phage/yeast library-based block-mutagenesis and parsimonious mutagenesis methodology. This process ensures significant improvements in the binding capacity of antibodies, leading to enhanced therapeutic efficacy.

Humanization

Our expert team performs the humanization of antibodies derived from non-human sources to reduce immunogenicity and enhance their compatibility with the human body. Through the replacement of rodent IgG sequences with human IgG sequences, we ensure optimal performance and safety of lead antibodies.

Fc Engineering

We offer Fc engineering services to modulate the functional activities of antibodies, including antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and in vivo half-life enhancement through interactions with Fc receptors. Our tailored Fc engineering strategies aim to optimize the therapeutic potential of lead antibodies for targeted oral disease treatment.

Drugability

The successful development of antibody drugs for oral diseases is critically dependent on drugability, and Alta Stomatology can provide you with drugability optimization services for lead antibody molecules. This service focuses on common issues in antibody drugs, including immunogenicity, post-translational modifications, and antibody aggregation. Our professional team will assist researchers in predicting and optimizing drugability during the antibody discovery phase, precisely addressing potential issues with antibodies. This ensures the generation of preclinical antibody candidates that not only exhibit functionality but also possess outstanding drugability.

Our Techniques

Phage display technology: Phage display is a powerful technique used to identify and optimize antibodies with high affinity and specificity for a target antigen.

Mutagenesis: Directed mutagenesis can be used to introduce specific changes to the antibody sequence to optimize its binding characteristics. This can involve mutating specific amino acids to improve affinity or specificity for the target antigen.

Protein engineering: Protein engineering techniques can be used to modify the antibody structure to improve its stability, pharmacokinetics, or other properties. This can involve introducing new disulfide bonds, altering the antibody glycosylation pattern, or other modifications.

Computational modeling: Computational modeling techniques can be used to predict the effects of mutations or structural changes on antibody-antigen interactions. This can help guide the design of optimized antibody variants.

Why Choose Alta Stomatology?

• Comprehensive Service

Alta Stomatology provides a one-stop service covering every aspect of lead antibody optimization. From humanization and affinity maturation to Fc engineering and comprehensive characterization, our services are designed to meet the diverse needs of lead optimization.

• State-of-the-Art Facilities

Our commitment to excellence is reflected in our state-of-the-art facilities. Alta Stomatology is equipped with cutting-edge laboratories, advanced equipment, and technology-driven platforms that enable us to conduct sophisticated lead antibody optimization with precision and efficiency.

• Unparalleled Expertise

Our team of scientists and researchers have extensive experience in lead antibody optimization and oral disease drug development. We have successfully optimized antibodies for a variety of therapeutic targets, this ensures that we can provide high-quality lead antibody optimization services to our clients.