Peptide molecules are mostly natural endogenous ligands with strong affinity to receptors and good selectivity, making them a class of molecules that are relatively easy to develop into lead compounds and drugs. Currently, the main problems faced in the development of peptide drugs include poor stability, short half-life, high plasma clearance rate, and other shortcomings in drug-like properties. Peptides typically can only be administered through injection, leading to poor patient compliance. Additionally, the production process is complex, resulting in high production costs. Therefore, rational modification and optimization of lead peptide molecules can reduce the production costs of peptide molecules and improve their drug-like properties. Alta Stomatology is a company dedicated to the research and development of peptide drugs for oral diseases. Our research and development team has extensive experience in peptide drug development and the field of oral diseases and can provide you with one-stop lead peptide optimization services. If you have any needs, please feel free to contact us.

Our Services

Improving Activity of Lead Peptide

At Alta Stomatology, we understand that the activity of peptide molecules is paramount for their development into effective drugs. Leveraging a repertoire of methodologies including N-Cap and C-terminal structural modifications, splicing strategies, cyclization, non-natural amino acid incorporation, pseudo-peptide strategies, cholesterol modification, and more, we enhance the affinity of lead peptides to their receptors, elevate the activity of lead peptides, bolstering their therapeutic potential for oral diseases.

Enhancing Pharmacological Stability of Lead Peptide

Peptide drugs face formidable challenges in achieving pharmacological stability, hindering their clinical utility. Alta Stomatology's expertise lies in fortifying peptide molecules against degradation by proteases, both in oral and injectable formulations. By employing innovative techniques such as non-natural amino acid modification, pseudo-peptide strategies, reverse peptide strategies, cyclization, advanced fatty acid modification, protein fusion, and polyethylene glycol modification, we augment the metabolic stability of peptides, amplifying their bioavailability and therapeutic efficacy.

Improving Permeability of Lead Peptide

Overcoming the barrier of cell membrane permeability is essential for the therapeutic success of peptide drugs. Through strategic modifications including halogen atom introduction, removal of polar side chains, chiral strategies, N-alkylation, and higher fatty acid modification, Alta Stomatology enhances the permeability of lead peptides. By optimizing their structure, we facilitate efficient cellular uptake, enabling peptides to exert their pharmacological effects with precision.

Enhancing Water Solubility of Lead Peptide

The water solubility of peptides plays a pivotal role in their clinical applicability. Alta Stomatology addresses this challenge through a series of strategies such as introducing pyridine groups, tailored to enhance the water solubility of lead peptides. By optimizing solubility, we ensure the efficacy and bioavailability of peptide compounds, facilitating their translation into clinically viable therapeutics.

Why Choose Alta Stomatology?

• Expertise in Peptide Drug Development

With years of experience in peptide research, Alta Stomatology possesses deep expertise in peptide drug design, synthesis, and optimization. Our team of scientists can overcome challenges associated with peptide development.

• Comprehensive Optimization Strategies

We offer a wide array of optimization strategies tailored to the unique properties and requirements of lead peptides. From the activity of peptide improvement to stability enhancements, our services cover all aspects of peptide optimization.

• Cutting-Edge Technology and Methodologies

Alta Stomatology utilizes state-of-the-art technology and innovative methodologies to drive peptide optimization. Our commitment to staying at the forefront of scientific advancements ensures that our clients receive the most effective solutions.