Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for Leukoplakia. Leukoplakia is defined as a predominantly white patch or plaque on the oral mucosa that cannot be wiped away and is not clinically or histologically characterised as any other definable disorder. At Alta Stomatology, we're dedicated to offering one-stop services for leukoplakia research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Oral hairy leukoplakia lesion of the tongue exhibiting a corrugated surface with hyperparakeratosis and numerous ballooning cells (Piperi E, et al., 2010)

Research on Leukoplakia

Oral leukoplakia (OL) is a white patch or plaque that develops in the oral cavity and is strongly associated with smoking. Oral leukoplakia is a potentially malignant disease affecting the oral mucosa. Histologically, oral leukoplakias present as either hyperkeratosis, mild dysplasia, moderate dysplasia, severe dysplasia, or carcinoma-in-situ. The exact underlying cause of leukoplakia is largely unknown, but it is likely multifactorial, with tobacco use being the primary factor. It cannot be erased or diagnosed as other definable necrosis by clinical and histopathological methods, and belongs to the category of precancerous lesions or potentially malignant disorders.

According to the clinical manifestations of oral leukoplakia, it is divided into two categories: homogeneous type and heterogeneous type. Homogeneous oral leukoplakia refers to lesions that are homogeneous white plaques or patchy lesions with clear boundaries. Heterogeneous oral leukoplakia refers to white patches or plaques accompanied by granular, nodular, erythema, ulcers or verrucous lesions. This type of oral leukoplakia has a relatively high risk of canceration. The standard management of leukoplakia is surgical excision, and follow-up is guided by histological diagnosis: 6-month intervals for OL without epithelial dysplasia and 3-month intervals for OL with epithelial dysplasia. However, this approach has shown limited efficacy in preventing clinical recurrence and malignant transformation.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on leukoplakia and its prevention and treatment. Chemoprevention can restrain the development of cancer by acting on various stages of carcinogenesis. Focusing on the development of safe and effective chemopreventive agents with minimal side effects, it is crucial to evaluate their effectiveness and safety. In recent years, there has been a growing interest in using biomarkers as a tool to improve the efficacy of response detection. These markers can provide valuable information about the biological processes underlying the development of cancer, allowing researchers to identify higher-risk individuals and monitor the response to chemopreventive interventions.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For leukoplakia disease, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of leukoplakia. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of oral mucosa disease.