Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for lichen planus pemphigoides. Lichen planus pemphigoides is a rare autoimmune blistering disorder with characteristics of both lichen planus and bullous pemphigoid. At Alta Stomatology, we're dedicated to offering one-stop services for lichen planus pemphigoides research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Direct immunofluorescence showing of lichen planus pemphigoides (Rameshkumar A, et al., 2015)

Research on Lichen Planus Pemphigoides, Lpp

Lichen planus pemphigoides (LPP) is a very rare autoimmune sub-epidermal blistering disease associated with lichenoid skin changes. Initially thought to be a mere variant of more common inflammatory dermatoses, particularly Bullous Pemphigoid (BP) or Lichen Planus, a growing body of evidence suggests that it is a disease entity in its own right. A key feature of LPP is the production of autoantibodies against type XVII collagen (COL17). The clinical presentation of LPP include blisters and erosions that appear on pre-existing lichenoid lesions and previously uninvolved skin. LPP frequently affects the upper and lower extremities but may involve other areas of the body, including nails and oral mucosa.

Oral LPP frequently affects the gingiva and buccal mucosa, presenting as desquamative gingivitis, Wickham striae, ulcerations, and/or bullae. The histopathologic features of LPP include lymphocyte-rich subepidermal bullae with occasional neutrophils and eosinophils. Necrotic keratinocytes may be detected in the roof of the blister. Bullae may arise within lichen planus lesions with the additional presence of neutrophils and eosinophils which differentiates LPP from bullous lichen planus.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on lichen planus pemphigoides and and its prevention and treatment. Diagnosis is based on careful correlation of the histopathological and immunopathological features, and the presence of autoantibodies binding to the dermal-epidermal junction. In LPP, two discrete primary skin lesions occur: lichenoid papules/plaques and tense blisters. Through molecular biology research, we will increase our knowledge and understanding of the pathogenesis of lichen planus pemphigoides.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For lichen planus pemphigoides disease, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of lichen planus pemphigoides. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of oral mucosa disease.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service