| Synonym(s): |
Niacinamide; Nicotinic acid amide; Pyridine-3-carboxylic acid amide; Vitamin B3; Vitamin PP |
| Formula: |
C6H6N2O |
| Description: |
Nicotinamide (NAM) belongs to the vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in the liver. NAM controls cell metabolism, redox reactions, mitochondrial functions, and energy generation. It promotes natural killer cell proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer’s, Parkinson’s, and Huntington’s diseases. |
| Application: |
Nicotinamide has been used as a medium supplement in the organoid culture of oral mucosa organoids, pancreatic cancer organoids, and pancreatic progenitor induction. |
| Color: |
White |
| Molecular Weight: |
122.12 |
| CAS Number: |
98-92-0 |
| EC Number: |
202-713-4 |
| InChI: |
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) |
| InChI Key: |
DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| MDL number: |
MFCD00006395 |
| NACRES: |
NA.75 |
| SMILES: |
NC(=O)c1cccnc1 |
| Solubility: |
Water: soluble 50 mg/mL, clear, colorless. |
| Form: |
Powder |
| Quality Level: |
200 |
| mp: |
128-131 °C (lit.) |
| Assay: |
≥ 98% (HPLC) |
