| Description: |
Neuregulin 1 (NRG1) is one of the four proteins in the neuregulin family that interact with the EGFR family of receptors. Initially identified as a 44-kilodalton glycoprotein, NRG1 binds to the NEU/ERBB2 receptor tyrosine kinase, enhancing its tyrosine phosphorylation. This trophic factor plays a significant role in neural development, neurotransmission, and synaptic plasticity. |
| Species: |
Human |
| Purity: |
> 98% as determined by SDS-PAGE. |
| Protein Construction: |
A DNA sequence encoding the human NRG1 isoform alpha extracellular domain (Ser 20-Lys 241) was fused with a polyhistidine tag at the C-terminus. |
| Endotoxin: |
< 1.0 EU per μg of the protein as determined by the LAL method. |
| Formulation: |
Lyophilized from sterile PBS, pH7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Shipping Condition: |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Storage Conditions: |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Expressed Host: |
HEK293 cells |
