Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for odontogenic fibroma. The odontogenic fibroma is a benign neoplasm of odontogenic ectomesenchymal origin, characterized by relatively mature collagenous fibrous tissue with varying amount of odontogenic epithelium. It can occur in central or peripheral location, the latter being more common by a 1.4:1 ratio. At Alta Stomatology, we're dedicated to offering one-stop services for odontogenic fibroma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Immunohistochemical analysis results of central odontogenic fibroma (Iordanidis S, et al., 2013)
Research on Odontogenic Fibroma
The odontogenic fibroma is a benign odontogenic neoplasm with central and peripheral variants. Both variants are characterized histopathologically by a fibrous proliferation with varying amounts of odontogenic epithelium. It typically presents as a well-circumscribed radiolucency, often inducing root resorption. Odontogenic fibroma consists of fibrous connective tissue with varying collagen density, ranging from loose, somewhat myxoid patterns to more mature collagen fibers. The tumor is classified as a neoplasm of odontogenic ectomesenchyme, with or without odontogenic epithelium.
Central odontogenic fibroma is a very rare proliferation of mature odontogenic mesenchyme. Generally the lesion is asymptomatic except the swelling of the jaw. The lesion may evolve from a dental germ (dental papilla or follicle) or from the periodontal membrane, and therefore is invariably related to the coronal or radicular portion of teeth. Radiographically the tumor sometimes produces an expansile multilocular radiolucency similar to that of the ameloblastoma. The peripheral odontogenic fibroma is characterized by a fibrous or fibromyxomatous proliferation that contains varying amounts of odontogenic or presumed odontogenic epithelium. It has been considered a rare gingival neoplasm.
Our Products
Vimentin Antibody
α-smooth Muscle Actin
CAM 5.2
Antibody Against High-molecular-weight Cytokeratins
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on odontogenic fibroma and and its prevention and treatment. To understand the biological behavior of odontogenic fibroma, studies on the stromal changes and odontogenic epithelium have been employed by various techniques ranging from histochemistry, immunohistochemistry, electron microscopy, and polymerase chain reaction.
| Langerhans Cells Examination |
Immunohistochemical Study |
- Embedding and sectioning
- Hematoxylin/eosin staining
- Microscope observation
|
- Hematoxylin/eosin staining
- Picrosirius red staining
- Streptavidin-biotin complex method
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For odontogenic fibroma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of odontogenic fibroma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. |
| Polarizing Microscopy |
Polarized light microscopy is used to study so-called transparent and opaque anisotropic materials. By measuring the polarized color exhibited by collagen fibers under a polarizing microscope, you can understand the sensitivity and specificity of staining and understand biological behavior. |
References
- Chi A. Odontogenic Fibroma. In: Slootweg, P.J. (eds) Dental and Oral Pathology. Encyclopedia of Pathology. 2016.
- Baiju CS, Sumidha R. Peripheral odontogenic fibroma: A case report and review. Journal of Indian Society of Periodontology. 2011; 15(3):p 273-275.
- Jahagirdar PB, et al. Stromal characterization and comparison of odontogenic cysts and odontogenic tumors using picrosirius red stain and polarizing microscopy: A retrospective and histochemical study. Indian J Cancer. 2015; 52(3):408-12.
- Iordanidis S, et al. Central odontogenic fibroma: report of case with immunohistochemical study. Indian J Dent Res. 2013; 24(6):753-5.
For research use only. Not
intended for any clinical use.
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