Odontogenic Myxoma/Myxoma/Myxofibroma
Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for odontogenic myxoma/myxoma/myxofibroma. Odontogenic myxoma is an intraosseous neoplasm that comprises 3-20% of all odontogenic tumors and is characterized by stellate and spindle-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. This tumor may lead to an extensive bone expansion and usually infiltrates the adjacent bone. At Alta Stomatology, we're dedicated to offering one-stop services for odontogenic myxoma/myxoma/myxofibroma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Lobular pattern where tumor had eroded through bone into the soft tissues with residual bony trabeculae seen between lobules (Hammad HM, et al., 2016)
Research on Odontogenic Myxoma/Myxoma/Myxofibroma
Myxoma of the jaws which was first described by Thoma and Goldman in 1947 is a rare neoplasm and its rate of prevalence and incidence is not available. Myxoma term, according to 1992 WHO classification, is used along with odontogenic myxoma (OM) and myxofibroma. There are two forms of myxomas or fibromyxomas that are recognised in head and neck region: one is derived from the facial skeleton and the other is derived from the soft tissue. Most of the OM are located intraosseously, but peripheral ones are also recognized.
The histogenesis of OM is most likely related to the odontogenic ectomesenchyme of a developing tooth or undifferentiated mesenchymal cells in the periodontal ligament and there are many theories that support the odontogenic origin of the OM. These theories are supported by the histological similarity between OM and pulpal ectomesenchyme, proximity to the tooth-bearing areas of the jaws, periodic association with missing or unerupted teeth, occasional presence of inactive odontogenic epithelium, and its uncommon occurrence in other parts of the skeleton.
Our Products
HMGA2 Break-apart Probes
Vimentin Antibody
Desmin Antibody
Actin Antibody
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on odontogenic myxoma/myxoma/myxofibroma and and its prevention and treatment. Molecular biology studies may help to identify the etiologic factors and to develop more effective and less aggressive approaches, other than surgery, to the treatment of odontogenic myxoma.
| Cytogenetic Study |
Molecular Biology Study |
- Hematoxylin and eosin staining
- Histochemical staining
- Immunohistochemical study
- Fluorescence in situ hybridization (FISH)
|
- Clonal nature
- Apoptosis and cell proliferation
- Genetic alterations
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For odontogenic myxoma/myxoma/myxofibroma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of odontogenic myxoma/myxoma/myxofibroma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. |
| Histopathological Examination |
Histopathology is the examination of tissues from the body under a microscope to spot the signs and characteristics of disease. Through histological examination, the structure, cellular composition and pathological characteristics of the tumor can be observed and described in detail. |
References
- Bahl S, et al. Central odontogenic fibromyxoma of mandible: an aggressive odontogenic pathology. BMJ Case Rep. 2016; 2016:bcr2016217303.
- Gomes CC, et al. Molecular review of odontogenic myxoma. Oral Oncol. 2011;47(5):325-8.
- Hammad HM, et al. Odontogenic myxoma with diffuse calcifications: a case report and review of a rare histologic feature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122(4):e116-24.
For research use only. Not
intended for any clinical use.
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