The oral immunity & infection research platform of Alta Stomatology is a leading platform in exploring oral immunity, the pathogenesis of oral diseases, and possible infection mechanisms. Besides having advanced experimental instruments, our platform is also equipped with a professional team. Our team of experienced researchers uses state-of-the-art technologies to research the complexities of oral immunity and infection mechanisms to improve oral health worldwide. We can provide high-quality services to support your research, whether you are interested in examining the genetic basis of periodontitis, mapping the transcriptomic landscape of the oral mucosa, or investigating immune cell interactions in oral immunity, we can provide high-quality services to support your research.

Our Fields of Oral Immunity & Infection Research

Dissecting Periodontitis Pathogenesis through Rare Disease

Periodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, remains a significant public health concern worldwide. Alta Stomatology is dedicated to unraveling the intricate mechanisms underlying periodontitis pathogenesis, leveraging insights from rare diseases with overlapping phenotypes. By studying these rare conditions, such as specific genetic disorders affecting immune function, we aim to uncover novel therapeutic targets and diagnostic biomarkers for periodontal diseases.

Human Cell Transcriptomic and Spatial Atlas of Oral Mucosa in Health and Disease

The oral mucosa serves as a critical barrier against microbial invasion and plays a pivotal role in orchestrating immune responses within the oral cavity. Alta Stomatology is undertaking a comprehensive analysis of the human oral mucosa at the transcriptomic and spatial levels, both in health and disease states. By deciphering the gene expression patterns and cellular interactions within the oral mucosa, Alta Stomatology aims to gain unprecedented insights into the dynamics of oral immunity and the dysregulation underlying infectious and inflammatory conditions.

Th17/Neutrophil Axis in Oral Immunity

The interplay between T helper 17 (Th17) cells and neutrophils represents a crucial axis in the immune defense against oral pathogens. Dysregulation of this axis has been implicated in various oral diseases, including periodontitis and oral candidiasis. Alta Stomatology is investigating the molecular mechanisms governing the Th17/neutrophil axis in oral immunity, aiming to delineate its role in health and disease. Through sophisticated experimental models and advanced molecular techniques, Alta Stomatology seeks to unravel the intricate crosstalk between Th17 cells, neutrophils, and resident oral microbes, offering new avenues for therapeutic intervention and immune modulation.

What We Can Do

Laboratory Equipment

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service