The oral microbiology research platform of Alta Stomatology aims to explore the mutual constraints and dependencies between microorganisms and hosts, as well as among microorganisms, elucidating the characteristics of the oral microbiota and its relationship with oral diseases, to maintain the balance between oral microbiota and the host organism. Additionally, this platform focuses on the etiology of common oral diseases such as dental caries, periapical diseases, periodontal diseases, and mucosal diseases, using dental plaque biofilms as the research subject and employing advanced techniques such as metabolomics, proteomics, and bioinformatics.

Oral Microbiology

Oral microbiology is the study of microorganisms that inhabit the oral cavity, including bacteria, fungi, viruses, and archaea. These microorganisms form complex communities known as oral microbiota, which play crucial roles in maintaining oral health and contributing to various oral diseases. Some of the key microorganisms studied in oral microbiology include:

Bacteria

Bacteria are the most abundant microorganisms in the oral cavity, with over 700 different species identified to date. These bacteria colonize various surfaces in the mouth, including the teeth, gums, tongue, and cheeks. Some common oral bacteria include Streptococcus mutans, Porphyromonas gingivalis, and Fusobacterium nucleatum.

Fungi

Fungi are another group of microorganisms found in the oral cavity, although they are less abundant compared to bacteria. Candida species are among the most commonly studied oral fungi and can contribute to conditions such as oral thrush and denture-related stomatitis.

Viruses

Viruses can also inhabit the oral cavity and may play a role in oral diseases such as cold sores (caused by the herpes simplex virus) and oral warts (caused by the human papillomavirus).

Archaea

Despite being less studied, archaea such as Methanobrevibacter oral have been identified within the oral cavity, suggesting their potential role in oral microbial communities.

Our Fields of Oral Microbial Research

At Alta Stomatology, our oral microbial research platform encompasses a wide range of research areas aimed at unraveling the complexities of the oral microbiome and its implications for oral health. Some of our key research focuses include:

Microbial Diversity and Dynamics

We are dedicated to characterizing the diversity of microorganisms present in the oral cavity and studying how these microbial communities change over time and in response to various factors such as diet, hygiene practices, and disease states.

Pathogenesis of Oral Diseases

We investigate the role of specific microorganisms in the development and progression of oral diseases, including dental caries, periodontal diseases, oral candidiasis, and oral cancer. By understanding the mechanisms by which these microorganisms contribute to disease, we aim to identify new targets for therapeutic intervention.

Host-Microbe Interactions

We study the interactions between oral microorganisms and the host immune system, epithelial cells, and other components of the oral mucosa. These interactions play a crucial role in determining whether oral microorganisms promote health or contribute to disease.

Biofilm Formation and Antimicrobial Resistance

We investigate the formation of microbial biofilms in the oral cavity and their role in oral diseases such as dental plaque and periodontitis. Additionally, we study mechanisms of antimicrobial resistance in oral bacteria and explore novel strategies to combat antibiotic-resistant pathogens.

Microbiome-Based Therapeutics

We are actively involved in the development of microbiome-based therapeutics for the prevention and treatment of oral diseases. These include probiotics, prebiotics, antimicrobial peptides, and other bioactive compounds that target specific oral microorganisms while preserving the balance of the oral microbiota.

What We Can Do

Laboratory Equipment

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service