Oral thin film (OTF) technology is an innovative technology for treating oral diseases that aims to solve the problems of difficulty in swallowing and poor bioavailability of traditional oral drug delivery methods. OTF is a polymer matrix in the form of a single or multilayer composite drug-carrying film that can dissolve rapidly in the oral cavity for quick drug release and absorption. As an expert in oral disease research, Alta Stomatology is committed to providing personalized OTF solutions for different types of oral diseases using advanced OTF technology. Please feel free to contact us for any of your needs.

Fig.1 Oral film as platform for drug delivery (He M., et al. 2021)

Key Benefits of OTF

Our Services

OTF presents as a thin and lightweight film that precisely targets oral lesions. It is highly suitable for treating common oral diseases such as recurrent aphthous ulcers (RAU) and gingivitis. At Alta Stomatology, we offer a diverse range of OTF solutions to address different needs in oral disease treatment. Our services encompass, but are not limited to:

OTF Formulation Development

Alta Stomatology is dedicated to developing diverse OTF formulations for oral diseases, covering antibacterial, anti-inflammatory, and analgesic drugs. By advancing innovative OTF technology, we also actively research and develop drugs that promote healing to expedite the repair and regeneration of oral mucosa.

OTF Drug Property Evaluation

With advanced analytical techniques and experimental equipment, Alta Stomatology can conduct a comprehensive and in-depth assessment of OTF drug properties such as solubility, stability, permeability, etc., to ensure the effective release and absorption of the drug.

Oral Mucosal Adhesion Study of OTF Drugs

Good oral mucosal adhesion is the key to ensuring the bioavailability of OTF drugs. Alta Stomatology focuses on the adhesion properties of OTF drugs on the oral mucosa, aiming to enhance the therapeutic efficacy and realize precise drug delivery.

ADME/DMPK Study of OTF Drugs

AS provides comprehensive ADME/DMPK services for OTF drugs. We control drug loading and release in OTF for effective oral release. Through in vitro and in vivo studies, we generate accurate reports to aid OTF drug development.

Application of OTF Technology in Oral Diseases

Recurrent Aphthous Ulcer

OTF technology can be applied to promote the healing of oral mucosa. In cases of oral ulcers, oral trauma, etc., OTF loaded with healing-promoting drugs can accelerate mucosal repair and shorten healing time.

Gingivitis and Periodontitis

OTF technology can load anti-inflammatory and pain-relieving drugs to effectively control oral inflammation, such as gingivitis and periodontitis, by adhering to the oral mucosa and improving gum health.

Dental Caries

OTF technology can be applied to treat dental caries. It acts directly on the infected oral area, rapidly and effectively inhibiting bacterial growth and enhancing the local antimicrobial effect.

Why Choose Alta Stomatology?

• Innovative OTF Technology

Alta Stomatology has advanced OTF technology and a research and development team that continues to drive innovation in treating oral diseases.

• State-of-the-Art Infrastructure

Our platforms are equipped with state-of-the-art instrumentation and technologies that allow us to perform ADME/DMPK studies on OTF drugs with precision and efficiency. From high-performance liquid chromatography (HPLC) systems to mass spectrometers and cell culture facilities, our state-of-the-art facilities provide reliable and reproducible data.

• Customized Solutions for OTF Drug Development

Alta Stomatology focuses on providing customized OTF drug development solutions for oral diseases. Considering the characteristics of various oral diseases, from common ones to complex oral mucosal lesions, we design the most suitable OTF formulations.