An organ-on-a-chip (OOC) is a multi-channel 3D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. Compared to common organoids, organ-on-a-chip is more controllable to the physicochemical microenvironment and is not easy to be contaminated. It has higher homogeneity in the size and shape of organ. In addition, it can achieve vascularization and exchange the nutrients and metabolic wastes in time. Organ-on-a-chip can very precisely re-create the mechanical and unique anatomical structures of the oral environment.

Highly bionic human micro-organ models constructed on organ-on-a-chip can reproduce the complex structures and physiological functions of human organs in vitro, thereby providing more accurate experimental data than two-dimensional static cell models and animal models. It plays an important role in disease modeling, drug development, etc. Considerable potential in the field of environmental toxicology is also shown.

Alta Stomatology provides oral organ-on-a-chip services to the scientific, medical and pharmaceutical industries and is committed to supporting research and development in the oral field. We have a professional team and advanced facilities to provide comprehensive oral organ-on-a-chip research support. If you have any needs, please feel free to contact us.

Fig.1 Illustration of different types of oral organ-on-a-chip. (Pierfelice TV, et al., 2024)

Our Services

Alta Stomatology can develop corresponding organ chips based on expected applications, provide an accurate and reliable experimental platform in drug development, disease research, toxicity assessment and personalized medicine, and promote progress and innovation in the biomedical field.

Alta Stomatology conducts disease modeling and preclinical efficacy studies using organ-on-a-chip technology in the fields of dental, oral and craniofacial (DOC) research. Alta Stomatology offers a range of high-quality bio-fabricated chip models, including:

Application

Why Choose Alta Stomatology?

• Expertise and Experience

Alta Stomatology boasts a team of seasoned professionals with extensive experience in oral disease research and oral organ establishment. Our expertise ensures the precision and reliability of our oral organ.

• Cutting-Edge Technology

We leverage the latest advancements in technology and methodology to ensure our organ' accuracy, reproducibility, and reliability. From advanced imaging techniques to sophisticated molecular assays, we employ diverse tools to drive oral disease research.

• Customized Solutions

We understand that each research project is unique, which is why we offer customized solutions designed to meet the specific requirements of our clients. Depending on your specific scientific research needs, we will work closely with you to develop a tailored approach that aligns with your research objectives.

• Commitment to Quality and Ethical Standards

At Alta Stomatology, we are committed to upholding the highest standards of quality, integrity, and ethical conduct in all aspects of our work. Our animal research practices adhere to strict regulatory guidelines and ethical principles, ensuring the welfare and humane treatment of all animals involved in our studies.