Organoid Development

Organoid Development

Organoids are 3D cell cultures grown in vitro using adult stem cells. They have highly similar histological characteristics to corresponding human organs and can reproduce some of the physiological functions of the organs. Oral organoids are complex 3-dimensional structures that develop from stem cells or organ-specific progenitors through a process of self-organization and re-create architectures and functionalities similar to in vivo organs and tissues in the oral and maxillofacial region.

Alta Stomatology provides oral organoid services to the scientific, medical and pharmaceutical industries and is committed to supporting research and development in the oral field. We have a professional team and advanced facilities to provide comprehensive oral organoid research support. If you have any needs, please feel free to contact us.

Fig.1 Schematic diagram of the construction of tooth germ organoid. (Gao X, et al., 2021)

Our Services

As an emerging biological model, organoids have unique advantages that cell lines and animal models do not have. Their cell composition and structure are more similar to human tissues, providing a highly physiologically relevant system and an excellent model for basic research. At the same time, organoid models are more economical and more time-effective than experimental animals, which can improve research efficiency.

In the field of oral disease research, establishing relevant models is crucial. As cutting-edge in vitro models, organoids have broad application prospects in many fields such as stem cells and development, regenerative medicine, disease research, drug development, and precision medicine. Alta Stomatology offers a range of high-quality oral organoids, including:

Salivary Gland Organoid

Oral Mucosal Melanoma Organoid

Oral Cancer Organoid

Lingual Epithelial Organoid

Maxillofacial Cartilage Organoid

Tooth Organoid

and more...

Oral Mucosal Organoid

Oral Esophageal Organoid

Tooth Germ Organoid

Taste Bud Organoid

Dental Follicle Organoid

Dental Pulp Organoid

In the organoid construction service, the scientific research and technical services that Alta Stomatology can provide are as follows:

  • Organoid Modeling Customized Service
  • Organoid Research Commercialization
  • Organoid-based Drug Development
  • Organoid Histopathological Testing

Application

Fundamental Research Drug R&D Clinical Transformation
  • Molecular biology analysis
  • Cytology research
  • Bioinformatics analysis
  • Drug screening
  • Pharmacological efficacy
  • Toxicological safety
  • POC verification
  • Biomarker discovery
  • Precision medicine

Advantages

Comparative Items Cell Line Mice Model PDX Model Organoid
Ease of establishing system /×
Ease of maintenance
Recapitulation of developmental biology × ×
Duration of experiments
Genetic manipulation ×
Genome-wide screening × ×
Physiological complexity ×
Relative cost
Recapitulation of human physiology
Note: best good partially suitable × unsuitable

Why Choose Alta Stomatology?

  • Expertise and Experience

Alta Stomatology boasts a team of seasoned professionals with extensive experience in oral disease research and oral organoid establishment. Our expertise ensures the precision and reliability of our oral organoid. 

  • Cutting-Edge Technology

We leverage the latest advancements in technology and methodology to ensure our organoid' accuracy, reproducibility, and reliability. From advanced imaging techniques to sophisticated molecular assays, we employ diverse tools to drive oral disease research.

  • Customized Solutions

We understand that each research project is unique, which is why we offer customized solutions designed to meet the specific requirements of our clients. Depending on your specific scientific research needs, we will work closely with you to develop a tailored approach that aligns with your research objectives.

  • Commitment to Quality and Ethical Standards

At Alta Stomatology, we are committed to upholding the highest standards of quality, integrity, and ethical conduct in all aspects of our work. Our animal research practices adhere to strict regulatory guidelines and ethical principles, ensuring the welfare and humane treatment of all animals involved in our studies.

Reference

  1. Gao X.; et al. Oral organoids: progress and challenges. J Dent Res. 2021, 100(5): 454-463.
For research use only. Not intended for any clinical use.
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