Organoids are 3D cell cultures grown in vitro using adult stem cells. They have highly similar histological characteristics to corresponding human organs and can reproduce some of the physiological functions of the organs. Oral organoids are complex 3-dimensional structures that develop from stem cells or organ-specific progenitors through a process of self-organization and re-create architectures and functionalities similar to in vivo organs and tissues in the oral and maxillofacial region.
Alta Stomatology provides oral organoid services to the scientific, medical and pharmaceutical industries and is committed to supporting research and development in the oral field. We have a professional team and advanced facilities to provide comprehensive oral organoid research support. If you have any needs, please feel free to contact us.
Fig.1 Schematic diagram of the construction of tooth germ organoid. (Gao X, et al., 2021)
As an emerging biological model, organoids have unique advantages that cell lines and animal models do not have. Their cell composition and structure are more similar to human tissues, providing a highly physiologically relevant system and an excellent model for basic research. At the same time, organoid models are more economical and more time-effective than experimental animals, which can improve research efficiency.
In the field of oral disease research, establishing relevant models is crucial. As cutting-edge in vitro models, organoids have broad application prospects in many fields such as stem cells and development, regenerative medicine, disease research, drug development, and precision medicine. Alta Stomatology offers a range of high-quality oral organoids, including:
Salivary Gland Organoid
Oral Mucosal Melanoma Organoid
Oral Cancer Organoid
Lingual Epithelial Organoid
Maxillofacial Cartilage Organoid
Tooth Organoid
and more...
Oral Mucosal Organoid
Oral Esophageal Organoid
Tooth Germ Organoid
Taste Bud Organoid
Dental Follicle Organoid
Dental Pulp Organoid
In the organoid construction service, the scientific research and technical services that Alta Stomatology can provide are as follows:
Fundamental Research | Drug R&D | Clinical Transformation |
---|---|---|
|
|
|
Comparative Items | Cell Line | Mice Model | PDX Model | Organoid |
Ease of establishing system | √/× | √ | √ | √ |
Ease of maintenance | √ | √ | √ | √ |
Recapitulation of developmental biology | × | √ | × | √ |
Duration of experiments | √ | √ | √ | √ |
Genetic manipulation | √ | √ | × | √ |
Genome-wide screening | √ | × | × | √ |
Physiological complexity | × | √ | √ | √ |
Relative cost | √ | √ | √ | √ |
Recapitulation of human physiology | √ | √ | √ | √ |
Note: √ best √ good √ partially suitable × unsuitable |
Alta Stomatology boasts a team of seasoned professionals with extensive experience in oral disease research and oral organoid establishment. Our expertise ensures the precision and reliability of our oral organoid.
We leverage the latest advancements in technology and methodology to ensure our organoid' accuracy, reproducibility, and reliability. From advanced imaging techniques to sophisticated molecular assays, we employ diverse tools to drive oral disease research.
We understand that each research project is unique, which is why we offer customized solutions designed to meet the specific requirements of our clients. Depending on your specific scientific research needs, we will work closely with you to develop a tailored approach that aligns with your research objectives.
At Alta Stomatology, we are committed to upholding the highest standards of quality, integrity, and ethical conduct in all aspects of our work. Our animal research practices adhere to strict regulatory guidelines and ethical principles, ensuring the welfare and humane treatment of all animals involved in our studies.
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