Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for osseous dysplasia. Osseous dysplasia, characterized by the replacement of normal bone with fibrous tissue containing mineralized substances consisting of bone, cementum, or both, belongs to the group of fibro-osseous lesions of the jaws. At Alta Stomatology, we're dedicated to offering one-stop services for osseous dysplasia research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Histologic appearance of a cemento-osseous dysplasia comprising spindle fibroblasts and cement-bone-like production (Günhan Ö, et al., 2021)
Research on Osseous Dysplasias
Osseous dysplasias, also known as fibro-osseous lesions, are a condition where normal bone is replaced by fibrous tissue and abnormally formed bone. These lesions can happen anywhere in the body but are most common in the jaw (mandible and maxilla). Painless and slow-growing, they are often discovered incidentally on dental x-rays with most patients not having any symptoms. Osseous dysplasias can be divided into three types: periapical cemental dysplasia, focal cemento-osseous dysplasia, and florid cemento-osseous dysplasia. These entities share similar microscopic features. The difference between these types lies in their locations in the mouth and the extent of the lesions.
Despite the benign nature of osseous dysplasias, they can sometimes cause complications. For example, in some cases where the normal bone is replaced, there may be inadequate blood supply leading to a condition called avascular necrosis. Osseous dysplasias was reported as the most common fibro-osseous lesion of the jaws in many studies. Although the aetiology and pathogenesis remain unknown, the lesions are assumed to originate from the periodontal ligament due to their proximity to the teeth and the formation of cementum-like calcifications and may be the result of an idiopathic/reactive response caused by a disturbance in bone metabolism.
Our Products
QIAamp DNA Blood Mini Kit
SureSelect Human All Exon V5 Kit
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on osseous dysplasia and and its prevention and treatment. Molecular analysis and protein expression studies are crucial for understanding osseous dysplasias pathogenesis. Insights into these molecular aspects can aid in diagnosis, prognosis, and targeted therapies.
| Molecular Analysis |
Protein Expression Study |
- Whole-exome sequencing (WES)
- DNA sequencing
- Signaling pathways study
|
- Immunohistochemistry
- Molecular marker diagnosis
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For osseous dysplasia disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of osseous dysplasia. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. Radiographic examination reveals a radiopaque mass, attached to the tooth root, bounded by a radiolucent halo, which is of variable and irregular thickness. |
| Histological Diagnosis |
Histological examination is a gold standard for the diagnosis of many pathological diseases, for which staining is an essential component. Once the tissue sample has undergone fixation, processing, embedding, sectioning, and staining, it can undergo analysis through microscopy. |
References
- Haefliger S, et al. Cemento-osseous dysplasia is caused by RAS-MAPK activation. Pathology. 2023; 55(3):324-328.
- Günhan Ö, et al. The possible pathogenesis of cemento-osseous dysplasia: A case series and discussion. Advances in Oral and Maxillofacial Surgery. 2021; 100105.
For research use only. Not
intended for any clinical use.
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