Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for ossifying fibroma. Ossifying fibroma is a benign, slowly progressive, nonaggressive tumor that is considered a type of fibro-osseous lesion. It is associated with the replacement of normal bone architecture with fibrous tissues and irregular bony deposits. At Alta Stomatology, we're dedicated to offering one-stop services for ossifying fibroma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Photomicrogaphs of juvenile ossifying fibroma trabecular variant (Nikitakis NG, et al., 2022)
Research on Ossifying Fibroma
Ossifying fibroma is defined as an encapsulated benign neoplasm composed of varying amounts of bone or cementum-like tissue in the fibrous tissue stroma. It is a slow-growing benign neoplasm that occurs most often in the jaws, especially the mandible. The tumor is composed of bone that develops within fibrous connective tissue. Ossifying fibroma is slow-growing and well-demarcated from the adjacent bone. Some lesions may grow to become massive, causing considerable aesthetic and functional deformities.
Ossifying fibroma most commonly occurs in patients in the second to fourth decades of life, although it may arise in children and adolescents, as well as in older adults. The mandible (particularly the molar region) is affected more often than the maxilla, whereas among the other cranial and facial bones, the periorbital, frontal, ethmoid, sphenoid, and temporal bones are also relatively common sites of this tumor.
Our Products
QIAamp DNA FFPE Tissue Kit
Tissue-Tek
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on ossifying fibroma and and its prevention and treatment. Genetic alterations and protein expression studies are crucial for understanding OF pathogenesis. Insights into these molecular aspects can aid in diagnosis, prognosis, and targeted therapies.
| Molecular Pathogenesis Study |
Protein Expression Study |
- Next-generation sequencing
- PCR array
- DNA Sequencing
|
- Immunohistochemistry
- Molecular marker diagnosis
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For ossifying fibroma disease, we can offer a variety of customized research services, including animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, oral organoid development, and bioinformatics analysis.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Bioinformatics Analysis
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of ossifying fibroma. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of odontogenic tumor disease.
| Diagnosis Methods |
Description |
| Radiography Examination |
We employ state-of-the-art radiography technology to obtain detailed images of the location of the lesion, type of lesion, etc., enabling our experts to accurately identify tumor occurring in the oral cavity. Radiographic examination reveals a radiopaque mass, attached to the tooth root, bounded by a radiolucent halo, which is of variable and irregular thickness. |
| Histological Diagnosis |
Histological examination is a gold standard for the diagnosis of many pathological diseases, for which staining is an essential component. Once the tissue sample has undergone fixation, processing, embedding, sectioning, and staining, it can undergo analysis through microscopy. |
References
- Jih MK, Kim JS. Three types of ossifying fibroma: A report of 4 cases with an analysis of CBCT features. Imaging Sci Dent. 2020; 50(1):65-71.
- Pereira TDSF, et al. The Wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125(2):172-178.
- Nikitakis NG, et al. Juvenile trabecular ossifying fibroma: Immunohistochemical expression of MDM2, CDK4 and p53 compared to conventional ossifying fibroma. J Clin Exp Dent. 2022; 14(1):e27-e34.
For research use only. Not
intended for any clinical use.
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