| This solution contains 10,000 units/mL of penicillin and 10,000 μg/mL of streptomycin. These antibiotics are utilized to prevent bacterial contamination in cell cultures due to their effective combined action against both gram-positive and gram-negative bacteria. Penicillin, originally purified from the fungi Penicillium, disrupts bacterial cell wall turnover and indirectly triggers the release of enzymes that further degrade the cell wall. Streptomycin, derived from Streptomyces griseus, binds to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis and causing death in susceptible bacteria. |
