Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for periapical granuloma. Periapical granulomas, a type of refractory periapical periodontitis, arise in response to the presence of oral bacteria and their products. At Alta Stomatology, we're dedicated to offering one-stop services for periapical granuloma research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Periapical Granuloma (Vieyra J.P, et al., 2015)
Research on Periapical Granuloma
Periapical granuloma, also sometimes referred to as a radicular granuloma or apical granuloma, is an inflammation at the tip of a dead (nonvital) tooth. It is a lesion or mass that typically starts out as an epithelial lined cyst, and undergoes an inward curvature that results in inflammation of granulation tissue at the root tips of a dead tooth. This is usually due to dental caries or a bacterial infection of the dental pulp. Periapical granuloma consists of a chronically inflamed granulation tissue, which is the most common periapical lesion, representing about 70 % of all lesions in the periapex.
In order to determine the pathological characteristics of periapical lesions, immunohistological analysis is widely used for protein expression in periapical granuloma. After performing immunoassay, molecular expression is analyzed through staining, PCR and other techniques. Data on these expressions may help to better understand its role in the immunopathogenesis of periapical granulomas. Inhibition of these expressed proteins may promote tissue healing and prevent disease progression.
Our Products
Monoclonal Antibody
R&D Staining Kit
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on immunohistochemical analysis and 3D cell culture model establishment. The expression of some proteins is related to the inflammatory process and is also related to the occurrence of tumors. Understanding the role of these substances may provide additional insights into the progression of periapical lesions. If the pathogenesis can be explained, it will be easier to carry out therapy. In vitro cell cultures are used to study and relate the mechanisms underlying cell behavior in vivo. 3D cell culture models have also been developed and designed for studying dental pulp regeneration and periodontal regeneration.
| Immunohistochemical Analysis |
Molecular Expression Test |
3D Cell Culture Model |
- ADAMTS expression
- MMP expression
- S100 expression
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- Dental pulp regeneration
- Periodontal regeneration
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Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For periapical granuloma diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis in treating periapical granuloma effectively. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of apical periodontitis disease.
| Diagnosis Methods |
Description |
| X-ray Radiograph |
We employ state-of-the-art X-ray technology to obtain detailed images of the teeth, enabling our experts to diagnose periapical inflammatory lesions. |
| Cone Beam Computed Tomography (CBCT) |
CBCT offers 3D evaluation of the maxillofacial region with minimal distortion. It can detect periapical lesions in many cases. CBCT scans provide a three dimensional evaluation of periapical pathology along with information of the canal morphology. |
References
- Li F-C, et al. 3D Organoids for Regenerative Endodontics. Biomolecules. 2023; 13(6):900.
- Batista, N.M.G, et al. Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst. BMC Oral Health. 2021; 21: 102.
- Vieyra J.P, et al. Relationship between Clinical and Histopathologic Findings of 40 Periapical Lesions. Dentistry 3000. 2015; 5(2): 1-7.
For research use only. Not
intended for any clinical use.
