Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for pulp hyperemia. Pulp hyperemia is a common pulp disease caused by the dilation of the arteries when the pulp is inflamed. At Alta Stomatology, we're dedicated to offering one-stop services for pulp hyperemia research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Research on Pulp Hyperemia
Pulp hyperemia, also known as reversible pulpitis, is a mild form of pulpitis. Patients with reversible pulpitis are prone to transient tooth pain. If the disease is not treated in time, it will infect the pulp tissue of the patient and bring great adverse effects on the oral health of the patient.
At present, the clinical treatment of reversible pulpitis mainly focuses on removing the irritation and preserving the viable pulp. Zinc oxide clove oil paste has strong analgesic, antibacterial and anti-inflammatory effects and is a commonly used pulp soothing material. Calcium hydroxide is the gold standard material used in vital pulp preservation treatments and is a commonly used pulp capping agent to preserve dental pulp vitality.
Fig.1 Histological photographs after treatment of pulpitis with botanical drugs (Nossa P. M., et al., 2013)
Our Products
Bipolar Enamel-coated Stainless Steel Wire Electrode
Lipo-polysaccharide (LPS)
Streptococcus Mutans
Tumor Necrosis Factor α (TNF-α) ELISA Kit
Hematoxylin-eosin (HE) Staining Kit
Rat Interleukin 1β (IL-1β) ELISA Kit
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on the development of soothing materials and auxiliary treatment materials for pulp hyperemia. Pulp soothing materials can be used to indirectly cover pulp, cushion deep caries or temporarily seal cavities, which can effectively relieve pulp pain, promote the elimination of pulpitis and protect pulp tissue of patients. Auxiliary treatment materials include temporary filling materials and indirect repair materials for pit and fissure sealing to assist in the treatment of pulp hyperemia. We strive to develop innovative materials that can alleviate or eliminate pulp hyperemia. Through comprehensive material characterization and testing, we aim to discover effective pulp soothing materials and auxiliary treatment materials that can aid in the prevention and management of pulp hyperemia.
Development of Treatment Materials for Pulp Hyperemia
| Development of Pulp Soothing Materials |
Development of Temporary Filling Materials |
- Calcium hydroxide or calcium silicate cements
- Zinc oxide clove oil paste
- Bioceramic materials
- New nano-bioceramic materials
|
- Silver amalgam
- Composite resin
- Glass ionomer
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For pulp hyperemia diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
For the establishment of animal model of pulp hyperemia, we can provide the rat and rabbit pulp hyperemia models.
| Animal Model Type |
Experimental Method |
| Rat Pulp Hyperemia Model |
The rat was anesthetized, and a cavity was prepared on the rat's mandibular first molar through an air turbine and a 1/2 tungsten carbide bur to expose the pulp point. Place the paper tip impregnated with lipo-polysaccharide into the cavity and temporarily seal it. |
| Rabbit Pulp Hyperemia Model |
New Zealand white rabbits were anesthetized and fixed, and the buccal and lingual surfaces of the bilateral mandibular incisors were disinfected with 75% ethanol by volume. Use a 0.5 mm ball drill to open the pulp on the lingual surface and drill to a depth of 9 mm to expose the pulp penetration point. After placing a cotton ball soaked in Streptococcus mutans solution at the pulp point, the tooth cavity is temporarily sealed. |
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of pulp hyperemia. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of apical periodontitis disease.
| Diagnosis Methods |
Description |
| X-ray Examination |
We use the most advanced X-ray technology to obtain detailed images of the pulp in order to accurately diagnose pulp congestion diseases. |
| Laser Doppler Flowmetry Examination |
Laser doppler flowmetry uses helium-neon or semiconductor as the laser light source. The detection principle is that the Doppler phenomenon absorbs the reflected light with frequency drift caused by the movement of blood cells, and the flow and flow rate of blood cells are detected based on the intensity and frequency shift of the reflected light. The test results can reflect the pulp blood flow and thereby determine the pulp vitality. |
References
- SUN X. lmprovement of pain and pulp vitality in patients with reversible pulpitis treated with minocycline combined with clove oil. World Compound Medicine. 2022; 8(9): 156-160.
- Nossa P. M., et al. Effects of the serjania erecta and zeyheria montana ethanol extracts in experimental pulpitis in rats: a histological study. Med Oral Patol Oral Cir Bucal. 2013; 18(2): e337-e342.
- Yong D, Cathro P. Conservative pulp therapy in the management of reversible and irreversible pulpitis. Aust Dent J. 2021; 66: S4-S14.
For research use only. Not
intended for any clinical use.
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