Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for pulp necrosis. Pulp necrosis is a common pulp disease caused by dental trauma, dental caries, and irreversible pulpitis. At Alta Stomatology, we're dedicated to offering one-stop services for pulp necrosis research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Research on Pulp Necrosis
Pulp necrosis is a common clinical pulp disease, which refers to the death of cells and tissues in the pulp cavity. Pulp necrosis is usually caused by dental trauma, dental caries, and irreversible pulpitis. The most common clinical symptoms of pulp necrosis are crown graying and periapical radiolucency. Pulp necrosis also destroys dentin, causing severe tooth pain. With the loss of tooth nutrition, teeth can become loose, cracked or even fall out.
The most basic treatment for pulp necrosis is root canal treatment. This involves the use of biologically acceptable mechanical and chemical treatments of the root canal system, followed by the placement of root canal filling material, allowing the periradicular tissue to heal. If the root of the tooth is not fully developed or the apex is not completely closed, pulp regeneration may be considered. Commonly used clinical methods for pulp regeneration are calcium hydroxide apexification technique, apical barrier technique with mineral trioxide aggregate, and regenerative endodontic procedures.
Our Products
Dental Pulp Stem Cell
Growth Factor
Biological Scaffold
Surgical Instruments for Laboratory
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on the development of root canal filling materials and scaffold materials for constructing pulp tissue. Root canal filling materials are also called root canal sealers, which are mainly used to fill root canals during root canal treatment, ensure complete sealing of the root canals and prevent reinfection. Biological scaffolds provide an environment for the adhesion, growth, proliferation, and differentiation of dental pulp stem cells, which is a necessary condition for dental pulp tissue regeneration. Through comprehensive materials characterization and testing, Alta Stomatology aims to discover effective pulp necrosis treatment materials to improve oral health worldwide.
Development of Treatment Materials for Pulp Necrosis
| Development of Root Canal Filling Materials |
Development of Scaffold Materials for Constructing Pulp Tissue |
- Zinc oxide eugenol sealers
- Calcium hydroxide sealers
- Glass ionomer sealers
- Resin sealers
- Bioceramic sealers
|
- Natural biomaterials: collagen, alginate, chitosan, hydroxyapatite, tricalcium phosphate, etc.
- Synthetic materials: polylactic acid, polyglycolic acid, lactic acid and glycolic acid copolymer, silk protein, self-assembled peptides, etc.
- Composite materials: hydroxyapatite, chitosan, polyhydroxyalkanoates, etc.
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For pulp necrosis diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of pulp necrosis. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of apical periodontitis disease.
| Diagnosis Methods |
Description |
| Pulse Oximeter Test |
The pulse oximeter test is a more accurate way to test for necrotic pulps as it primarily tests for vascular health of the pulp as compared to its nervous response. In a study of deciduous and immature permanent teeth, the results clearly reflected that pulse oximeter can easily differentiate between viable and nonviable necrotic teeth. |
| MRI Scan Test |
MRI scans have been used to detect and evaluate several areas of the head and neck, including the temporomandibular joints, salivary glands, floor of the mouth, etc. Research shows that MRI scans are a promising tool in diagnosing pulp necrosis. |
References
- Guide to clinical endodontics 6th edition. American Association of Endodontics. 2016.
- Kahler B, et al. An evidence-based review of the efficacy of treatment approaches for immature permanent teeth with pulp necrosis. J Endod. 2017; 43(7):1052-1057.
- Assaf AT, et al. Early detection of pulp necrosis and dental vitality after traumatic dental injuries in children and adolescents by 3-Tesla magnetic resonance imaging. J Craniomaxillofac Surg. 2015; 43(7):1088-1093.
For research use only. Not
intended for any clinical use.
