| Synonym(s): |
R-spondin-1; RSPO1; CRISTIN3; FLJ40906; RP11-566C13.1; RSPO |
| Description: |
RSPO1, also known as R-spondin-1 protein, serves as a potent activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6, RSPO1 associates with phosphorylated LRP6 and frizzled receptors, which are activated by extracellular Wnt signals. This interaction initiates the canonical Wnt signaling cascade, resulting in enhanced expression of target genes. RSPO1 also regulates the canonical Wnt/beta-catenin pathway and non-canonical Wnt signaling by inhibiting ZNRF3, a critical modulator of Wnt signaling. Moreover, RSPO1 acts as a ligand for frizzled FZD8 and LRP6, potentially modulating the TGF-beta pathway negatively. |
| Purity: |
Greater than 95% as determined by Tris-Bis PAGE. |
| Formulation: |
Supplied as a 0.22 μm filtered solution of 20 mM MES, 150 mM NaCl, 200 mM Arginine, 10% glycerol, pH5.5. |
| Shipping: |
Shipping with dry ice. |
| Storage: |
Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles. |
| Molecular Weight: |
40-50 kDa |
| Appearance: |
Solution |
| Source: |
HEK293 |
| Species: |
Mouse |
| Tag: |
C-His |
