Radiation Osteomyelitis/Osteoradionecrosis
Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for radiation osteomyelitis. Osteoradionecrosis is best defined as a slow-healing radiation-induced ischemic necrosis of bone with associated soft tissue necrosis of variable extent occurring in the absence of local primary tumour necrosis, recurrence or metastatic disease. At Alta Stomatology, we're dedicated to offering one-stop services for radiation osteomyelitis research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.
Fig.1 Mandibular osteoradionecrosis (Debnam JM, 2011)
Research on Radiation Osteomyelitis/Osteoradionecrosis
Osteoradionecrosis (ORN) of the jaws is one of the most severe and debilitating complications following radiation therapy for head and neck cancer patients. It is a radiation-induced ischaemic necrosis of bone with associated soft tissue necrosis occurring in the absence of primary tumour, recurrence, or metastatic disease. The incidence of ORN ranges from 5% to 15% and is most frequently noted (>70%) in the first three years after completion of treatment.
Mandibular ORN is more prevalent when compared to the maxilla due to the relatively poor vascularisation and to the dense structure of mandibular bone. Mandibular ORN often presents with bone tissue necrosis and chronic inflammation. The common clinical manifestations are local redness, swelling, pain, difficulty chewing and swallowing, limited mouth opening, facial soft tissue fistula overflowing with pus that does not heal, exposure of dead bones, and in severe cases, pathological fractures.
Our Products
Ketamin
Rompun
Biological Irradiator
Demeclocycline
Our Services
At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on radiation osteomyelitis and and its prevention and treatment. Use histological analysis to study the underlying cellular mechanisms of disease and contribute to treatment and diagnosis. The fluorochrome labeling patterns can be highly suggestive of cell necrosis occurring in the extraction site.
| Histological Analysis |
Fluorescent Microscopic Analysis |
- Decalcification treatment
- Hematoxylin and eosin (H&E) staining
- Light microscopy examination
|
- Fluorochrome labeling
- UV light microscopy examination
|
Analysis Services
- Polymerase Chain Reaction (PCR)
- Liquid Chromatography Mass Spectrometry (LC-MS)
- Electrophoresis Technology
- Enzyme Linked Immunosorbent Assay (ELISA)
Customized Research Services
With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For radiation osteomyelitis disease, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.
Animal Model Establishment
Drug Screening
In Vitro and In Vivo Study
Novel Drug Delivery System
Oral Organoid Development
Our Diagnosis Methods
At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of radiation osteomyelitis. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of jaw disease.
| Diagnosis Methods |
Description |
| Radiographic Examination |
We employ state-of-the-art radiographic technology to obtain detailed images of the jaw, enabling our experts to accurately identify lesions occurring in the jaw. |
| Micro-computed Tomography (micro-CT) |
Micro-CT makes use of an x-ray source and detector to obtain 2D images of a sample that, in turn, can be combined to create a 3D reconstruction. Through Micro-CT analysis, we can obtain a complete three-dimensional (3D) image containing the experimental area and surrounding trabeculae. |
References
- Rice N, et al. The management of osteoradionecrosis of the jaws-a review. Surgeon. 2015; 13(2):101-9.
- Seo MH, et al. Development of a standardized mucositis and osteoradionecrosis animal model using external radiation. J Korean Assoc Oral Maxillofac Surg. 2020, 46(4):240-249.
- Debnam JM. Imaging of the Head and Neck following Radiation Treatment. Patholog Res Int. 2011; 2011:607820.
For research use only. Not
intended for any clinical use.
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