| Target: |
IL-1 beta (Interleukin 1, beta (IL-1β)) |
| Protein Type: |
Recombinant |
| Origin: |
Rhesus monkey |
| Source: |
E. coli |
| Sequence: |
APVRSLHCTL RDAQLKSLVM SGPYELKALH LQGQDLEQQV VFSMSFVQGE ESNDKIPVAL GLKAKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTRGG QDITDFTMQF VS |
| Characteristics: |
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of D10.G4.1 mouse helper T cells is typically 3-10pg/mL,corresponding to a specific activity of >1 x 108 units/mg. |
| Purification: |
Purified by proprietary chromatographic techniques |
| Purity: |
> 98 % by SDS-PAGE and HPLC analyses. |
| Format: |
Lyophilized |
| Reconstitution: |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. stock solutions should be apportioned into working aliquots and stored at |
| Storage: |
4°C |
| Expiry Date: |
12 months |
| Alternative Name: |
Interleukin-1 beta (IL-1beta) |
| Synonyms: |
IL-1, IL1-BETA, IL1F2, IL-1BETA, IL1beta, il1-b, zgc:111873, IL-1B, IL-1beta, Il-1b, IL1B, IL-1 beta, IL-1b, interleukin 1 beta, interleukin 1, beta, IL1B, il1b, Il1b. |
| Background: |
IL-1 beta, a proinflammatory cytokine, is generated in various cell types such as monocytes, tissue macrophages, keratinocytes, and epithelial cells. Both IL-1 alpha and IL-1 beta bind to the same receptor and exhibit similar if not identical, biological effects. These cytokines possess diverse activities, including promoting thymocyte proliferation by inducing IL-2 release, facilitating B-cell maturation and proliferation, exhibiting mitogenic FGF-like properties, and triggering the release of prostaglandin and collagenase from synovial cells. However, IL-1 beta is primarily secreted, while IL-1 alpha predominantly remains associated with cells. The mature rhesus IL-1 beta, with a molecular weight of 17 kDa, shares a remarkable 96% amino acid sequence identity with its human counterpart. |
| Molecular Weight: |
Approximately 17.3 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids. |
