Tissue microarray (TMA) is a powerful tool that allows the analysis of hundreds of unique tissue samples at once. This high-throughput method significantly reduces the time, tissue, and reagents required for sample analysis compared to traditional methods. TMA has become a popular choice in the diagnosis, treatment, and research of various oral diseases as it provides a cost-effective and efficient way to screen for markers and study tissue samples in a large-scale manner.

Alta Stomatology is a leading oral disease research company, we offer a comprehensive tissue microarray analysis service that can help researchers in the dental field to study and understand oral diseases more efficiently and cost-effectively. If you have any needs, please feel free to contact us.

Our Services

Tissue Sample Collection and Preparation

Our team of skilled technicians will prepare tissue samples according to your specific requirements, ensuring they are of the highest quality for analysis. Our preparation process includes:

Tissue Fixation

Proper fixation of tissues to preserve morphology and molecular integrity.

Embedding and Sectioning

Embedding tissues in paraffin blocks and sectioning them with precision.

Slide Preparation

Preparing slides for subsequent staining and analysis.

TMA Construction

Once the tissue samples have been collected and prepared, our team constructs the TMA by precisely arranging them on a single slide. This process allows for hundreds of tissue samples to be analyzed simultaneously, maximizing efficiency and reducing costs. Our TMA construction services include:

Core Selection

Identifying representative tissue cores from each sample.

Array Design

Designing the layout of the TMA block to accommodate hundreds of cores.

Punching and Arraying

Using a precision instrument to punch out tissue cores and arrange them into a recipient block.

Histological and Immunohistochemical Staining

We offer a range of staining techniques to highlight specific cellular components and molecular markers within the tissue samples. Our staining services include:

Hematoxylin and Eosin (H&E) Staining

Providing a general overview of tissue morphology.

Immunohistochemistry (IHC)

For detecting specific proteins and biomarkers.

In Situ Hybridization (ISH)

For detecting specific nucleic acid sequences.

Digital Pathology and Image Analysis

To enhance the accuracy and efficiency of our analyses, we employ digital pathology tools and image analysis software. These services include:

High-Resolution Scanning

Converting stained slides into high-resolution digital images.

Automated Image Analysis

Using software to quantify staining intensity and marker expression.

Data Management

Organizing and storing digital images and analysis results for easy access and review.

Data Interpretation and Reporting

Once the analysis is complete, our team of experts interprets the data and generates a comprehensive report detailing the findings of the TMA analysis. The report includes a summary of the results, detailed explanations of key findings, and recommendations for further research or treatment strategies.

Applications of TMA in Oral Disease Research

In the field of oral disease research, TMA has proven to be an invaluable tool. It facilitates a variety of applications, including:

Biomarker Discovery

TMAs enable the high-throughput screening of potential biomarkers for oral diseases, such as oral cancer, periodontitis, and oral lichen planus. Identifying reliable biomarkers is crucial for early diagnosis, prognosis, and the development of targeted therapies.

Drug Development and Testing

Pharmaceutical companies can use TMAs to test the efficacy and safety of new drugs on a wide range of tissue samples. This accelerates the oral disease drug development process and facilitates the identification of patient-specific therapeutic responses.

Pathogenesis Studies

Understanding the molecular mechanisms underlying oral diseases is essential for developing effective treatments. TMAs allow researchers to investigate the expression of key proteins and genes involved in disease pathogenesis, providing insights into disease progression and potential therapeutic targets.

Advantages of TMA

High Throughput

TMA can analyze hundreds of tissue samples in a single experiment, which is particularly advantageous for large-scale studies and clinical trials.

Reduced Variability

By processing multiple samples under identical conditions, TMA significantly reduces the variability that often plagues traditional marker screening methods.

Resource Efficiency

TMA requires less tissue material and fewer reagents, which not only conserves resources but also lowers the overall cost of research.

Speed

The ability to analyze many samples simultaneously accelerates the research process, allowing for quicker turnaround times in obtaining results.

Consistency

TMAs provide consistent conditions across all samples, ensuring that any observed differences are due to the samples themselves and not the experimental setup.

Why Choose Alta Stomatology?

• Expertise and Experience

Our team consists of experienced pathologists, histotechnologists, and drug development researchers who have extensive expertise in TMA technology, oral disease research, and drug development. Our wealth of technical knowledge and experience enables us to handle a wide range of complex samples and research needs.

• State-of-the-Art Facilities

We utilize cutting-edge equipment and technology for TMA construction, staining, and digital pathology. Our facilities are equipped with advanced imaging systems and software, enabling precise and detailed analysis.

• Comprehensive Services

From sample collection to data interpretation, we offer a one-stop TMA service. Our integrated approach ensures seamless project execution and reliable results. Whether it is sample preparation, TMA construction, histological and immunohistochemical staining, or digital pathology and image analysis, we provide high-quality services to meet the diverse needs of our clients.

• Cost-Effectiveness

By reducing sample-to-sample variability and the amount of time, tissue, and reagents required, TMA technology itself offers significant cost-efficiency. Alta Stomatology further ensures cost control for our clients by optimizing processes and implementing effective project management, all while delivering high-quality services.