Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for tuberculous osteomyelitis. Bony tuberculosis of the jaw is an uncommon form of extrapulmonary tuberculosis and is very rare. Tuberculosis of the jaw is more common in children below the age of 18 years. At Alta Stomatology, we're dedicated to offering one-stop services for tuberculous osteomyelitis research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Panoramic radiograph of the mandible showing diffuse radiolucency (Koul PA, et al., 2014)

Research on Tuberculous Osteomyelitis

Tuberculosis is considered an emerging disease worldwide. Tuberculosis is rarely confined to bone and develops frequently secondary to a systemic infection. However, oral presentation with bone involvement occurs in less than 3% of all reported cases. The clinical lesions of oral tuberculosis present as painful and irregular ulcers, especially in the posterior tongue area, pharynx, or palate, and they are frequently secondary to active pulmonary tuberculosis. Sometimes, bone invasion can lead to tuberculosis-related osteomyelitis.

The tongue and gingiva are the most common sites of infection. Other sites include tooth socket, the soft palatethe floor of mouth, lips, buccal mucosa, jaws, maxillary antrum and salivary glands. The clinical presentations of oro-facial tuberculosis may be ulcers, granulomas, tuberculous osteomyelitis of the jaws, tuberculous salivary glands and tuberculous lymphadenitis. Tuberculous osteomyelitis of the maxilla is an extremely rare condition of the oral cavity. It can present in an unusual form in the oral cavity and can be misdiagnosed. Mandibular osteomyelitis caused by M. tuberculosis infection is also a rare medical condition. The mechanism of propagation of tuberculosis infection to the mandibular bone can be by direct inoculation through dental extraction, lesions of the mucosa during teeth eruption, and spread from adjacent tissue or via a hematogenous route.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on tuberculous osteomyelitis and and its prevention and treatment. In lesions of tuberculous osteomyelitis, histopathology plays a major role in determining the final diagnosis and subsequent course of treatment. Simple and rapid molecular diagnosis is the basic method to establish early and effective medical and surgical treatment.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For tuberculous osteomyelitis disease, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of tuberculous osteomyelitis. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of jaw disease.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service